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Opioid Analgesic
Opioid analgesics bind to opioid receptors in the central and peripheral nervous system to reduce the perception of pain.
Opioid analgesics bind to opioid receptors in the central and peripheral nervous system to reduce the perception of pain. Used for Moderate to severe acute pain, Chronic pain management.
At a glance
| Generic name | Opioid Analgesic |
|---|---|
| Also known as | Conventional Opioid based analgesia |
| Sponsor | Vanderbilt University Medical Center |
| Drug class | Opioid analgesic |
| Target | Opioid receptors (mu, delta, kappa) |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
These drugs activate mu, delta, and kappa opioid receptors, which modulate pain signaling pathways and alter the emotional response to pain. By binding to these G-protein coupled receptors, opioids decrease neurotransmitter release and hyperpolarize neurons, resulting in analgesia, sedation, and euphoria.
Approved indications
- Moderate to severe acute pain
- Chronic pain management
- Cancer pain
Common side effects
- Constipation
- Nausea
- Drowsiness
- Dizziness
- Respiratory depression
- Dependence and addiction
Key clinical trials
- Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery (PHASE1)
- Management of Pain in Lumbar Arthrodesis (PHASE4)
- Prospective Evaluation of Intrathecal Targeted Drug Delivery for Cancer Associated Pain
- Compared Reversed US-Guided Dorsal Penile Nerve Block (RUSDPNB) With DPNB in Circumcisions for Pediatric Patients (NA)
- The Analgesic Efficacy and Safety of Venlafaxine for Prevention of Postherpetic Neuralgia in Patients With Acute Herpes Zoster (NA)
- Intercostal Nerve Cryoablation Versus Epidural Analgesia for Nuss Repair of Pectus Excavatum (NA)
- Continous Infusion of Nefopam for Patients Undergoing Pancreatoduodenectomy (PHASE4)
- Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Opioid Analgesic CI brief — competitive landscape report
- Opioid Analgesic updates RSS · CI watch RSS
- Vanderbilt University Medical Center portfolio CI