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Morphine Patient Controlled Analgesia
Morphine binds to opioid receptors in the central nervous system to block pain signal transmission and provide analgesia.
Morphine binds to opioid receptors in the central nervous system to block pain signal transmission and provide analgesia. Used for Acute postoperative pain, Acute moderate to severe pain in hospitalized patients.
At a glance
| Generic name | Morphine Patient Controlled Analgesia |
|---|---|
| Also known as | MORPHİNE PCA |
| Sponsor | Istituti Ospitalieri di Cremona |
| Drug class | Opioid analgesic |
| Target | Mu-opioid receptor (μ-OR) |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
Morphine is a mu-opioid receptor agonist that acts on the central nervous system to reduce the perception of pain and emotional response to pain. Patient-controlled analgesia (PCA) is a delivery method that allows patients to self-administer doses of morphine within programmed safety limits, improving pain control and patient satisfaction. This formulation is used in acute postoperative and acute pain management settings.
Approved indications
- Acute postoperative pain
- Acute moderate to severe pain in hospitalized patients
Common side effects
- Respiratory depression
- Nausea and vomiting
- Constipation
- Dizziness
- Pruritus
- Sedation
Key clinical trials
- Serratus Plane Block (SPB) Versus Capsaïcine Versus Botox-A for Chronic Neuropathic Pain in Post-mastectomy Syndrome (PHASE2)
- Continous Infusion of Nefopam for Patients Undergoing Pancreatoduodenectomy (PHASE4)
- Comparison of Intrathecal Morphine and Rectus Sheath Block for Postoperative Pain Management After Lower Abdominal Surgery With Midline Incision (NA)
- Effect of CYP2D6 on Perioperative Analgesia of Oxycodone in Elderly Patients
- Analgesic Techniques for Robotic Prostatectomy Procedures (NA)
- Efficacy And Safety Of Tramadol And Oxycodone Versus Oxycodone Monotherapy For Pain Control After Primary Total Knee And Total Hip Arthroplasty (PHASE4)
- Pain Control After Open Radical Nephrectomy: Thoracic Paravertebral Block Versus External Oblique Intercostal Block (NA)
- The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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