Galderma R&D

Quick facts

Marketed products

• ABPO Forte Gel · Dermatology
  ABPO Forte Gel is a topical formulation containing azelaic acid that reduces bacterial colonization and normalizes keratinization to treat acne and rosacea.
• adapalen 0.1%
• Adapalene 0.1% and Benzoyl Peroxide 2.5% gel
• adapalene/benzoyl peroxide · Dermatology
  Adapalene is a retinoid that normalizes skin cell differentiation and reduces inflammation, while benzoyl peroxide is an antimicrobial that kills acne-causing bacteria and reduces sebum production.
• Adapalene/benzoyl peroxide gel, 0.1%/2.5% · Dermatology
  Adapalene is a retinoid that normalizes skin cell differentiation and reduces inflammation, while benzoyl peroxide kills acne-causing bacteria and provides additional antimicrobial activity.
• Adapalene Gel, 0.1% · Dermatology
  Adapalene is a third-generation retinoid that binds to retinoic acid receptors (RARs) to normalize skin cell differentiation and reduce inflammation in acne.
• Adapalene Gel, 0.1% + Tazarotene Cream, 0.1% · Dermatology
  This combination product delivers two retinoid receptor agonists that normalize skin cell differentiation and reduce inflammation to treat acne and photoaging.
• adapalene gel, 0.3% · Dermatology
  Adapalene is a third-generation retinoid that binds to retinoic acid receptors (RARs) to normalize skin cell differentiation and reduce inflammation.
• Advanced Eye Relief · Ophthalmology
  Advanced Eye Relief is an over-the-counter ophthalmic lubricant and decongestant that reduces eye redness and irritation by moisturizing the ocular surface and constricting blood vessels.
• Alluzience · Other
• azelaic acid 15% gel · Dermatology
  Azelaic acid reduces bacterial colonization and normalizes keratinization while exerting anti-inflammatory and antimicrobial effects on the skin.
• Azzalure · Other
• Azzalure or Dysport · Dermatology / Aesthetics
  Azzalure is a botulinum toxin type A that blocks acetylcholine release at the neuromuscular junction, paralyzing facial muscles and reducing wrinkles.
• Bifonazole Cream · Dermatology / Infectious Disease
  Bifonazole is an imidazole antifungal that disrupts fungal cell membrane integrity by inhibiting ergosterol synthesis.
• BPO · Dermatology
  BPO (benzoyl peroxide) kills acne-causing bacteria and reduces sebum production while promoting skin cell turnover.
• Brimonidine 0.33% gel (Br) · Dermatology
  Brimonidine is an alpha-2 adrenergic agonist that constricts blood vessels and reduces redness in the skin.
• Calcipotriene and betamethasone dipropionate ointment · Dermatology
  This combination ointment uses calcipotriene (a vitamin D analog) to normalize skin cell differentiation and betamethasone dipropionate (a potent corticosteroid) to reduce inflammation and immune activation in psoriatic plaques.
• Cetaphil · Other
• "Cetaphil Healing Ointment" · Dermatology
  Cetaphil Healing Ointment creates a protective barrier on the skin while providing emollient and humectant ingredients to promote wound healing and skin repair.
• Ciclopirox NL · Dermatology/Infectious Disease
  Ciclopirox is a broad-spectrum antifungal agent that inhibits fungal enzyme systems by chelating polyvalent cations, disrupting cellular respiration and biosynthesis.
• Clobetasol Propionate, 0.05% · Dermatology
  Clobetasol propionate is a potent corticosteroid that suppresses inflammatory and immune responses by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.
• Clobetasol Propionate 0.05% Foam · Dermatology
  Clobetasol propionate is a potent topical corticosteroid that suppresses inflammatory and immune responses in the skin by binding to glucocorticoid receptors.
• Clobex Spray · Dermatology
  Clobex Spray is a potent topical corticosteroid that suppresses inflammatory and immune responses in the skin.
• Facial Cleanser and Moisturizer SPF 30 · Dermatology
  This topical product provides physical and chemical sun protection while cleansing and moisturizing the facial skin.
• Facial Moisturizer with SPF 50+ · Dermatology
  This product provides physical and chemical UV protection to prevent sun damage while delivering hydration to facial skin.
• Ivermectin 1% cream (IVM) · Dermatology
  Ivermectin binds to glutamate-gated chloride channels in parasites and arthropods, causing paralysis and death of the organisms.
• Lidocaine 7% + Tetracaine 7% cream · Dermatology / Pain Management
  Lidocaine and tetracaine are local anesthetics that block sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce topical anesthesia.
• Loceryl Nail Lacquer · Dermatology
  Amorolfine inhibits fungal sterol synthesis by blocking lanosterol demethylase, disrupting the integrity of the fungal cell membrane.
• Loceryl NL · Dermatology
  Loceryl is an antifungal nail lacquer that inhibits fungal cell wall synthesis by disrupting ergosterol production.
• Loceryl NL 12 weeks · Dermatology / Infectious Disease
  Loceryl is a topical antifungal that inhibits fungal sterol synthesis by blocking lanosterol 14α-demethylase, disrupting the fungal cell membrane.
• Loceryl NL 15 months · Dermatology
  Amorolfine is a morpholine antifungal that inhibits fungal sterol synthesis by blocking both Δ14-reductase and Δ8-Δ7-isomerase enzymes in the ergosterol biosynthesis pathway.
• Loceryl NL + Cosmetic varnish · Dermatology
  Amorolfine is a morpholine antifungal that inhibits fungal sterol synthesis by blocking both Δ14-reductase and Δ8-Δ7-isomerase enzymes in the ergosterol biosynthesis pathway.
• Methyl Aminolaevulinate 16% Cream · Dermatology
  Methyl aminolaevulinate is a photosensitizing prodrug that accumulates in abnormal skin cells and generates reactive oxygen species when activated by red light, destroying target lesions.
• Metronidazole gel 1% · Dermatology
  Metronidazole disrupts bacterial and protozoal DNA by generating reactive oxygen species and damaging nucleic acids, leading to cell death.
• Oracea · Other
• Oral doxycycline hyclate · Infectious Disease
  Doxycycline hyclate is a tetracycline antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit.
• powder BoNT-A (BOTOX/Vistabel) · Dermatology; Neurology; Aesthetics
  Botulinum toxin type A blocks acetylcholine release at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.
• Product A
  Product A is a marketed pharmaceutical from Galderma R&D, but specific mechanistic details are not provided.
• Product B · Dermatology
  Product B is a marketed dermatological agent from Galderma R&D, but specific mechanistic details are not publicly available.
• Retin-A Micro Microsphere 0.1% · Dermatology
  Retin-A Micro delivers tretinoin (a vitamin A derivative) in microsphere form to normalize skin cell turnover and reduce comedone formation.

Phase 3 pipeline

• Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel · Dermatology
  Adapalene is a retinoid that normalizes skin cell differentiation and reduces inflammation, while benzoyl peroxide kills acne-causing bacteria and provides additional antimicrobial activity.
• Adapalene 0.3% / BPO 2.5% gel · Dermatology
  Adapalene is a retinoid that normalizes skin cell differentiation and reduces inflammation, while benzoyl peroxide provides antimicrobial activity against acne-causing bacteria.
• Adapalene BPO · Dermatology
  Adapalene is a retinoid that binds to retinoic acid receptors to normalize skin cell differentiation and reduce inflammation, while benzoyl peroxide provides antimicrobial activity against acne-causing bacteria.
• adapalene lotion 0.1% · Dermatology
  Adapalene is a topical retinoid that works by binding to retinoic acid receptors, modulating gene expression and promoting cell turnover.
• Adapalene Lotion Vehicle · Dermatology
  Adapalene is a third-generation retinoid that binds to retinoic acid receptors to normalize skin cell differentiation and reduce inflammation in acne.
• Benzoyl Peroxide Gel 2.5% · Dermatology
  Benzoyl peroxide kills acne-causing bacteria and promotes skin cell turnover by generating reactive oxygen species.
• botulinum toxin neuromodulator · Neurology, Aesthetics, Pain Management
  Botulinum toxin blocks acetylcholine release at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.
• c-PDT · Dermatology
  c-PDT is a photodynamic therapy approach that uses a photosensitizing agent activated by light to generate reactive oxygen species and destroy target cells.
• C. propionate - Corticosteroid 1 · Dermatology
  Clobetasol propionate is a potent topical corticosteroid that suppresses inflammatory and immune responses in the skin by binding to glucocorticoid receptors.
• C. propionate- Corticosteroid 2 · Dermatology
  Clobetasol propionate is a potent corticosteroid that suppresses inflammatory and immune responses by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.
• C. propionate -Corticosteroid 3 · Dermatology
  Clobetasol propionate is a potent topical corticosteroid that suppresses inflammatory and immune responses in the skin by binding to glucocorticoid receptors.
• CD0271 · Dermatology
  CD0271 is a selective inhibitor of phosphodiesterase 4 (PDE4) that reduces inflammatory mediator production in immune cells.
• CD0271 0.1% / CD1579 2.5% · Dermatology
  CD0271 and CD1579 are topical agents that work synergistically to reduce skin inflammation and improve dermatological conditions through complementary anti-inflammatory pathways.
• CD0271 0.3% / CD1579 2.5% · Dermatology
  CD0271 and CD1579 are topical agents that work synergistically to reduce inflammation and improve skin barrier function in dermatological conditions.
• CD07805/47 gel · Dermatology
  CD07805/47 gel is a topical retinoid that modulates skin cell differentiation and reduces inflammation for acne treatment.
• CD07805/47 gel 0.5%/CD07805/47 Vehicle · Dermatology
  CD07805/47 is a topical retinoid that modulates retinoid receptor signaling to reduce inflammation and promote skin cell differentiation in dermatological conditions.
• CD1579 · Dermatology
  CD1579 is a selective inhibitor of phosphodiesterase 4 (PDE4) that reduces inflammatory mediator production in immune cells.
• CD5789 (trifarotene) · Dermatology
  Trifarotene is a selective retinoid X receptor (RXR) agonist that modulates gene expression to reduce inflammation and promote skin cell differentiation.
• Clobex® Shampoo · Dermatology
  Clobetasol propionate is a potent topical corticosteroid that suppresses inflammatory and immune responses in the skin.
• Clobex® Vehicle Shampoo · Dermatology
  Clobex Vehicle Shampoo delivers clobetasol propionate, a potent topical corticosteroid, to the scalp to reduce inflammation and suppress immune-mediated skin responses.
• Corticosteroid 1- C. propionate · Dermatology
  Clobetasol propionate is a potent corticosteroid that suppresses inflammatory and immune responses by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.
• Corticosteroid 2 - C. propionate · Dermatology
  Clobetasol propionate is a potent corticosteroid that suppresses inflammatory and immune responses by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.
• Corticosteroid 3 - C. propionate · Dermatology
  Clobetasol propionate is a potent corticosteroid that suppresses inflammatory and immune responses by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.
• Drug: CD07805/47 gel · Dermatology
  CD07805/47 gel is a topical retinoid that promotes skin cell turnover and collagen remodeling to improve signs of photoaging and wrinkles.
• Epiduo/Tactuo · Dermatology
  Epiduo/Tactuo combines adapalene (a retinoid) and benzoyl peroxide to reduce acne by normalizing skin cell turnover and killing acne-causing bacteria.
• GK567 · Endocrinology / Diabetes
  GK567 is a glucokinase activator that enhances glucose metabolism in pancreatic beta cells to stimulate insulin secretion.
• ketoconazole shampoo (2/week) · Dermatology
  Ketoconazole shampoo inhibits fungal growth by disrupting ergosterol synthesis in fungal cell membranes, reducing dandruff and seborrheic dermatitis.
• MAL 16.8% cream · Dermatology
  MAL 16.8% cream is a topical formulation of methyl aminolevulinate that generates reactive oxygen species upon light activation to destroy abnormal skin cells.
• MAL Vehicle Cream · Dermatology
  MAL Vehicle Cream is a topical formulation vehicle designed to deliver active pharmaceutical ingredients through the skin for localized therapeutic effect.
• Metronidazole 0.75% cream · Dermatology
  Metronidazole disrupts bacterial and protozoal DNA, leading to cell death and reduction of microorganisms associated with rosacea and other inflammatory skin conditions.
• Metvix and conventional PDT · Oncology / Dermatology
  Metvix is a photosensitizing agent that accumulates in abnormal skin cells and, when activated by light in photodynamic therapy (PDT), generates reactive oxygen species to destroy lesions.
• Metvix and natural daylight PDT · Oncology/Dermatology
  Metvix (methyl aminolevulinate) is a photosensitizing agent that accumulates in abnormal skin cells and is activated by natural daylight to generate reactive oxygen species that destroy lesions.
• Metvix cream · Dermatology/Oncology
  Metvix (methyl aminolevulinate) is a photosensitizing agent that accumulates in abnormal cells and generates reactive oxygen species when activated by light, destroying target lesions.
• NDL-PDT · Dermatology
  NDL-PDT is a photodynamic therapy agent that generates reactive oxygen species upon light activation to destroy targeted tissue.
• QM1114-DP · Dermatology
  QM1114-DP is a topical treatment that targets the inflammatory pathways in the skin.
• tretinoin 0.05% emollient cream · Dermatology
  Tretinoin is a retinoid that promotes skin cell turnover and reduces acne by unclogging pores.

Phase 2 pipeline

• AbobotulinumtoxinA dose 1 · Dermatology
  AbobotulinumtoxinA is a botulinum toxin type A that works by temporarily paralyzing muscles to reduce muscle spasms and improve muscle tone.
• AbobotulinumtoxinA dose level 1 or 2 · Dermatology
  AbobotulinumtoxinA is a botulinum toxin type A that works by temporarily paralyzing muscle contractions.
• Betneval ointment - Non-desquamated zone
  Likely acts as a topical corticosteroid with anti-inflammatory and immunosuppressive properties on intact skin.
• Botulinum Toxin Type A - Vistabel · Neurology
  Inhibits acetylcholine release at the neuromuscular junction
• CD 2027
• CD07223 · Oncology
  CD07223 is a small molecule targeting the CD73 enzyme.
• CD10367 1% Solution - Non-desquamated zone · Dermatology
  CD10367 is a topical solution designed to treat non-desquamated (non-scaling) skin lesions, likely through anti-inflammatory or keratolytic activity.
• CD10367 3% Solution - Desquamated zone · Dermatology
  CD10367 3% Solution - Desquamated zone is a topical treatment that helps to remove the outer layer of the skin, reducing the appearance of desquamation.
• CD10367 3% Solution - Non-desquamated zone · Dermatology
  CD10367 3% Solution - Non-desquamated zone is a topical treatment for acne.
• CD11301 0.03%
• CD11301 0.06% · Dermatology
  CD11301 is a topical retinoid that modulates the retinoic acid pathway to treat acne.
• CD14152 Dose A
• CD1579 2.5%
• CD1579 5% · Dermatology
  CD1579 5% is a topical retinoid that modulates cell growth and differentiation.
• CD5024 0.3% cream · Dermatology
  CD5024 0.3% cream is a topical calcineurin inhibitor that suppresses the immune system by inhibiting T-cell activation.
• CD5024 1% cream
• CYP 450 Substrates · Other
  CYP 450 substrates inhibit the activity of the cytochrome P450 enzyme system.
• NP000888

Phase 1 pipeline

• adapalene cream 0.1% and adapalene lotion 0.1%
• METVIXIA Cream

Competitive intelligence

For the full portfolio CI brief — phase mix, recent regulatory actions, upcoming PDUFA dates, patent timeline, class-overlap with competitors:

• Galderma R&D portfolio CI brief
• Galderma R&D pipeline updates RSS

Frequently asked questions about Galderma R&D

Related

• ABPO Forte Gel · Dermatology
• adapalen 0.1%
• Adapalene 0.1% and Benzoyl Peroxide 2.5% gel
• adapalene/benzoyl peroxide · Dermatology
• Adapalene/benzoyl peroxide gel, 0.1%/2.5% · Dermatology
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