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Clobex® Vehicle Shampoo
Clobex Vehicle Shampoo delivers clobetasol propionate, a potent topical corticosteroid, to the scalp to reduce inflammation and suppress immune-mediated skin responses.
Clobex Vehicle Shampoo delivers clobetasol propionate, a potent topical corticosteroid, to the scalp to reduce inflammation and suppress immune-mediated skin responses. Used for Inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses of the scalp.
At a glance
| Generic name | Clobex® Vehicle Shampoo |
|---|---|
| Sponsor | Galderma R&D |
| Drug class | Topical corticosteroid (Class I/super-potent) |
| Target | Glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | Phase 3 |
Mechanism of action
Clobetasol propionate is a Class I (super-potent) corticosteroid that binds to glucocorticoid receptors in skin cells, suppressing inflammatory cytokine production and immune cell infiltration. When formulated as a shampoo vehicle, it provides convenient topical delivery to the scalp while maintaining the anti-inflammatory and antipruritic effects characteristic of potent corticosteroids.
Approved indications
- Inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses of the scalp
Common side effects
- Application site burning or stinging
- Application site irritation
- Folliculitis
- Skin atrophy (with prolonged use)
Key clinical trials
- Maintenance Effect of Clobex Shampoo on Participants With Moderate to Severe Scalp Psoriasis (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Clobex® Vehicle Shampoo CI brief — competitive landscape report
- Clobex® Vehicle Shampoo updates RSS · CI watch RSS
- Galderma R&D portfolio CI