{"id":"clobex-vehicle-shampoo","safety":{"commonSideEffects":[{"rate":null,"effect":"Application site burning or stinging"},{"rate":null,"effect":"Application site irritation"},{"rate":null,"effect":"Folliculitis"},{"rate":null,"effect":"Skin atrophy (with prolonged use)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Clobetasol propionate is a Class I (super-potent) corticosteroid that binds to glucocorticoid receptors in skin cells, suppressing inflammatory cytokine production and immune cell infiltration. When formulated as a shampoo vehicle, it provides convenient topical delivery to the scalp while maintaining the anti-inflammatory and antipruritic effects characteristic of potent corticosteroids.","oneSentence":"Clobex Vehicle Shampoo delivers clobetasol propionate, a potent topical corticosteroid, to the scalp to reduce inflammation and suppress immune-mediated skin responses.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:42:08.251Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses of the scalp"}]},"trialDetails":[{"nctId":"NCT00400725","phase":"PHASE3","title":"Maintenance Effect of Clobex Shampoo on Participants With Moderate to Severe Scalp Psoriasis","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2006-09-29","conditions":"Scalp Psoriasis","enrollment":288}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Clobex® Vehicle Shampoo","genericName":"Clobex® Vehicle Shampoo","companyName":"Galderma R&D","companyId":"galderma-r-d","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Clobex Vehicle Shampoo delivers clobetasol propionate, a potent topical corticosteroid, to the scalp to reduce inflammation and suppress immune-mediated skin responses. Used for Inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses of the scalp.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}