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Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel
Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel is a Retinoid + Peroxide combination Small molecule drug developed by Galderma R&D. It is currently in Phase 3 development for Acne vulgaris. Also known as: Adapalene-BPO gel.
Adapalene is a retinoid that normalizes skin cell differentiation and reduces inflammation, while benzoyl peroxide kills acne-causing bacteria and provides additional antimicrobial activity.
Adapalene is a retinoid that normalizes skin cell differentiation and reduces inflammation, while benzoyl peroxide kills acne-causing bacteria and provides additional antimicrobial activity. Used for Acne vulgaris.
At a glance
| Generic name | Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel |
|---|---|
| Also known as | Adapalene-BPO gel |
| Sponsor | Galderma R&D |
| Drug class | Retinoid + Peroxide combination |
| Target | Retinoic acid receptors (adapalene); bacterial cell membrane and proteins (benzoyl peroxide) |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | Phase 3 |
Mechanism of action
Adapalene binds to retinoic acid receptors to regulate gene expression, reducing comedone formation and normalizing follicular keratinization. Benzoyl peroxide acts as an oxidizing agent that generates reactive oxygen species, killing Cutibacterium acnes (formerly Propionibacterium acnes) and reducing bacterial resistance. The combination targets multiple pathogenic mechanisms of acne: follicular obstruction, bacterial proliferation, and inflammation.
Approved indications
- Acne vulgaris
Common side effects
- Erythema
- Dryness
- Peeling
- Irritation
- Photosensitivity
Key clinical trials
- Experience With Topical Acne Treatment (EARLY_PHASE1)
- Study to Demonstrate the Efficacy and Safety of Adapalene/Benzoyl Peroxide Topical Gel in Subjects With Acne Vulgaris (PHASE3)
- Long-term Study of Efficacy/Safety of Adapalene/Benzoyl Peroxide Topical Gel in Acne Vulgaris Subjects (PHASE3)
- Pirfenidone Plus M-DDO Gel in Moderate and Severe Acne (PHASE1, PHASE2)
- A Treatment Regimen for Student Athletes With Mild to Moderate Acne Vulgaris (PHASE4)
- Adapalene BPO Gel Pump, Moisturizer SPF 30 and Foam Wash in Patients With Mild to Moderate Acne Vulgaris (PHASE4)
- Assessment of Subjects' Efficacy and Experiences Using Adapalene BPO Gel in the Treatment of Acne Vulgaris (PHASE4)
- Evaluate Effectiveness of Epiduo® Gel in Reducing Antibiotic Sensitive & Resistant Strains of Propionibacterium (P)Acnes (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel CI brief — competitive landscape report
- Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel updates RSS · CI watch RSS
- Galderma R&D portfolio CI
Frequently asked questions about Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel
What is Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel?
How does Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel work?
What is Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel used for?
Who makes Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel?
Is Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel also known as anything else?
What drug class is Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel in?
What development phase is Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel in?
What are the side effects of Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel?
What does Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel target?
Related
- Drug class: All Retinoid + Peroxide combination drugs
- Target: All drugs targeting Retinoic acid receptors (adapalene); bacterial cell membrane and proteins (benzoyl peroxide)
- Manufacturer: Galderma R&D — full pipeline
- Therapeutic area: All drugs in Dermatology
- Indication: Drugs for Acne vulgaris
- Also known as: Adapalene-BPO gel
- Compare: Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel vs similar drugs
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