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Evaluation of the Effectiveness of Epiduo® Gel (Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel) in Reducing Antibiotic Sensitive and Resistant Strains of P Acnes
The purpose of this study is to evaluate the effectiveness of Epiduo® Gel in reducing antibiotic sensitive and resistant strains of P acnes in vivo.
Details
| Lead sponsor | Galderma R&D |
|---|---|
| Phase | Phase 4 |
| Status | COMPLETED |
| Enrolment | 30 |
| Start date | 2009-06 |
| Completion | 2009-07 |
Conditions
- P Acnes Colonization
Interventions
- Adapalene 0.1%/Benzoyl Peroxide 2.5% Gel (Epiduo® Gel)
Primary outcomes
- Change From Baseline in Quantitative Bacteriology Measurements at Week 4 — Week 4
Mean log10 values of P. acnes from swabbed skin samples Please note: Quantitative bacteriologic cultures were obtained from the facial skin (forehead) at screening, baseline, week 2 and week 4/early termination. Samples were obtained according to a modification of the technique of Williamson and Kligman. CFUs of P. acnes were counted at the dilution that contained between 10 and 100 CFUs. Total densities of P. acnes were calculated and reported as the average (of both plates) of the log10 CFUs per cm².
Countries
United States