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Corticosteroid 3 - C. propionate
Clobetasol propionate is a potent corticosteroid that suppresses inflammatory and immune responses by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.
Clobetasol propionate is a potent corticosteroid that suppresses inflammatory and immune responses by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production. Used for Severe inflammatory dermatological conditions (e.g., severe psoriasis, lichen planus, severe eczema), Short-term treatment of severe dermatitis and pruritic conditions.
At a glance
| Generic name | Corticosteroid 3 - C. propionate |
|---|---|
| Also known as | Corticosteroid 3 compared to CP Shampoo |
| Sponsor | Galderma R&D |
| Drug class | Corticosteroid (topical, Class I/super-potent) |
| Target | Glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | Phase 3 |
Mechanism of action
Clobetasol propionate is a Class I (super-potent) topical corticosteroid that works by activating intracellular glucocorticoid receptors, leading to decreased production of inflammatory mediators and reduced immune cell infiltration. It is used to treat severe inflammatory skin conditions where rapid anti-inflammatory and immunosuppressive effects are needed.
Approved indications
- Severe inflammatory dermatological conditions (e.g., severe psoriasis, lichen planus, severe eczema)
- Short-term treatment of severe dermatitis and pruritic conditions
Common side effects
- Skin atrophy
- Striae
- Telangiectasia
- Systemic corticosteroid absorption (with prolonged use or occlusion)
- Local irritation or burning
Key clinical trials
- Subject Preference for Scalp Psoriasis Treatment (PHASE3)
- Evaluation Inhaled Corticosteroids on Exhaled Nitric Oxide Gas Exchange
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Corticosteroid 3 - C. propionate CI brief — competitive landscape report
- Corticosteroid 3 - C. propionate updates RSS · CI watch RSS
- Galderma R&D portfolio CI