{"id":"corticosteroid-3-c-propionate","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin atrophy"},{"rate":null,"effect":"Striae"},{"rate":null,"effect":"Telangiectasia"},{"rate":null,"effect":"Systemic corticosteroid absorption (with prolonged use or occlusion)"},{"rate":null,"effect":"Local irritation or burning"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Clobetasol propionate is a Class I (super-potent) topical corticosteroid that works by activating intracellular glucocorticoid receptors, leading to decreased production of inflammatory mediators and reduced immune cell infiltration. It is used to treat severe inflammatory skin conditions where rapid anti-inflammatory and immunosuppressive effects are needed.","oneSentence":"Clobetasol propionate is a potent corticosteroid that suppresses inflammatory and immune responses by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:07:49.524Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Severe inflammatory dermatological conditions (e.g., severe psoriasis, lichen planus, severe eczema)"},{"name":"Short-term treatment of severe dermatitis and pruritic conditions"}]},"trialDetails":[{"nctId":"NCT00438399","phase":"PHASE3","title":"Subject Preference for Scalp Psoriasis Treatment","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2007-02","conditions":"Scalp Psoriasis","enrollment":219},{"nctId":"NCT00568347","phase":"","title":"Evaluation Inhaled Corticosteroids on Exhaled Nitric Oxide Gas Exchange","status":"COMPLETED","sponsor":"Arthur F Gelb MD","startDate":"2006-01","conditions":"COPD","enrollment":39}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Corticosteroid 3 compared to CP Shampoo"],"phase":"phase_3","status":"active","brandName":"Corticosteroid 3 - C. propionate","genericName":"Corticosteroid 3 - C. propionate","companyName":"Galderma R&D","companyId":"galderma-r-d","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Clobetasol propionate is a potent corticosteroid that suppresses inflammatory and immune responses by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production. Used for Severe inflammatory dermatological conditions (e.g., severe psoriasis, lichen planus, severe eczema), Short-term treatment of severe dermatitis and pruritic conditions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}