Last reviewed 2026-04-22 · How we verify

Bifonazole Cream

Bifonazole is an imidazole antifungal that disrupts fungal cell membrane integrity by inhibiting ergosterol synthesis.

Bifonazole is an imidazole antifungal that disrupts fungal cell membrane integrity by inhibiting ergosterol synthesis. Used for Fungal skin infections including dermatophytosis, candidiasis, and pityriasis versicolor, Tinea pedis, tinea corporis, tinea cruris.

At a glance

Mechanism of action

Bifonazole works by inhibiting the fungal enzyme lanosterol 14α-demethylase (part of the cytochrome P450 system), which is essential for ergosterol synthesis in fungal cell membranes. This leads to accumulation of toxic sterol precursors and depletion of ergosterol, causing membrane destabilization and fungal cell death. It is effective against a broad spectrum of dermatophytes, yeasts, and other fungi.

Approved indications

• Fungal skin infections including dermatophytosis, candidiasis, and pityriasis versicolor
• Tinea pedis, tinea corporis, tinea cruris

Common side effects

• Local irritation or burning at application site
• Erythema
• Pruritus

Key clinical trials

• Treatment of Onychomycosis With Loceryl (Amorolfine) Nail Lacquer 5% Versus a Two-course Treatment With Urea 40% Ointment and Bifonazole Cream 1% (PHASE4)
• Comparative Efficacy of Bifonazole Cream vs Placebo After Nail Ablation With Urea Paste (PHASE3)
• Efficacy and Safety of RV4104A Ointment in Onychomycosis (NA)

Primary sources

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