{"id":"bifonazole-cream","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or burning at application site"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Pruritus"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bifonazole works by inhibiting the fungal enzyme lanosterol 14α-demethylase (part of the cytochrome P450 system), which is essential for ergosterol synthesis in fungal cell membranes. This leads to accumulation of toxic sterol precursors and depletion of ergosterol, causing membrane destabilization and fungal cell death. It is effective against a broad spectrum of dermatophytes, yeasts, and other fungi.","oneSentence":"Bifonazole is an imidazole antifungal that disrupts fungal cell membrane integrity by inhibiting ergosterol synthesis.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:28:24.906Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Fungal skin infections including dermatophytosis, candidiasis, and pityriasis versicolor"},{"name":"Tinea pedis, tinea corporis, tinea cruris"}]},"trialDetails":[{"nctId":"NCT02705664","phase":"PHASE4","title":"Treatment of Onychomycosis With Loceryl (Amorolfine) Nail Lacquer 5% Versus a Two-course Treatment With Urea 40% Ointment and Bifonazole Cream 1%","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2016-01","conditions":"Foot Dermatoses","enrollment":22},{"nctId":"NCT00781820","phase":"PHASE3","title":"Comparative Efficacy of Bifonazole Cream vs Placebo After Nail Ablation With Urea Paste","status":"COMPLETED","sponsor":"Bayer","startDate":"2008-10","conditions":"Onychomycosis","enrollment":693},{"nctId":"NCT00808366","phase":"NA","title":"Efficacy and Safety of RV4104A Ointment in Onychomycosis","status":"UNKNOWN","sponsor":"Pierre Fabre Dermo Cosmetique","startDate":"2008-10","conditions":"Onychomycosis","enrollment":228}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"ANAEMIA"},{"count":1,"reaction":"DEHYDRATION"},{"count":1,"reaction":"HYPERKALAEMIA"},{"count":1,"reaction":"RENAL FAILURE ACUTE"}],"_approvalHistory":[],"publicationCount":56,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Bifonazole"],"phase":"marketed","status":"active","brandName":"Bifonazole Cream","genericName":"Bifonazole Cream","companyName":"Galderma R&D","companyId":"galderma-r-d","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bifonazole is an imidazole antifungal that disrupts fungal cell membrane integrity by inhibiting ergosterol synthesis. Used for Fungal skin infections including dermatophytosis, candidiasis, and pityriasis versicolor, Tinea pedis, tinea corporis, tinea cruris.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}