Last reviewed 2026-04-22 · How we verify

Clobex Spray

Clobex Spray is a potent topical corticosteroid that suppresses inflammatory and immune responses in the skin.

Clobex Spray is a potent topical corticosteroid that suppresses inflammatory and immune responses in the skin. Used for Inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses (e.g., psoriasis, lichen planus, atopic dermatitis), Severe inflammatory skin conditions requiring potent topical corticosteroid therapy.

At a glance

Mechanism of action

Clobetasol propionate, the active ingredient, binds to glucocorticoid receptors in skin cells and immune cells, reducing the production of inflammatory cytokines and mediators. This leads to decreased inflammation, itching, and skin lesion severity in inflammatory dermatological conditions. As a Class I (super-potent) corticosteroid, it is among the strongest topical steroids available.

Approved indications

• Inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses (e.g., psoriasis, lichen planus, atopic dermatitis)
• Severe inflammatory skin conditions requiring potent topical corticosteroid therapy

Common side effects

• Skin atrophy
• Striae
• Telangiectasia
• Folliculitis
• Hypertrichosis
• Systemic corticosteroid absorption (with prolonged use or occlusion)

Key clinical trials

• Subject Reported Target-lesion Numeric Rating Scale Evaluation by Subjects With Plaque Psoriasis Treated With Clobex® (Clobetasol Propionate) Spray 0.05% (PHASE4)
• Clobetasol Propionate Spray Versus Vehicle Spray for the Management of Moderate to Severe Plaque Psoriasis of the Scalp (PHASE4)
• Efficacy/Safety/Subject Satisfaction/Duration of Response of Clobetasol Propionate Spray vs Ointment in Plaque Psoriasis (PHASE4)
• Safety & Effectiveness of Clobex Spray, Followed by Calcitriol Ointment in Management of Plaque Psoriasis (PHASE3)
• Evaluate Safety/Efficacy of Two Treatment Regimens for Vectical™ Ointment & Clobex® Spray for Moderate Plaque Psoriasis (PHASE4)
• Efficacy, Safety, Preference and Response Duration of Clobex® Spray and Taclonex® Ointment in Psoriasis (PHASE4)
• A Comparison Between Clobetasol Propionate 0.05% (Clobex®) Spray and Clobetasol Propionate 0.05% (Olux®) Foam (PHASE4)
• Efficacy, Tolerance and Satisfaction With CLOBEX® Spray When Used as Monotherapy or Add-on Therapy in Plaque Psoriasis

Primary sources

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