Last reviewed 2026-04-23 · How we verify

adapalene lotion 0.1%

Adapalene is a topical retinoid that works by binding to retinoic acid receptors, modulating gene expression and promoting cell turnover.

Adapalene is a topical retinoid that works by binding to retinoic acid receptors, modulating gene expression and promoting cell turnover. Used for Acne vulgaris, Aging skin.

At a glance

Mechanism of action

This leads to increased cell turnover, reduced comedogenesis, and improved skin appearance. Adapalene's mechanism is similar to other retinoids, but its unique formulation allows for better penetration and reduced irritation.

Approved indications

• Acne vulgaris
• Aging skin

Common side effects

• Skin irritation
• Dryness
• Redness

Key clinical trials

• Tolerability Comparison Between Differin® Cream 0.1% Versus Differin® Lotion 0.1% in Subjects With Healthy Skin (PHASE1)
• Tolerability Comparison of Differin® Cream 0.1% Versus Differin® Lotion 0.1% in Subjects With Healthy Skin (PHASE1)
• Clinical Study to Test the Efficacy and Safety of Adapalene, 0.1% (PHASE3)
• Comparison of Four Different Regimens of Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel in Acne Vulgaris (PHASE3)
• Clinical Study to Test the Efficacy and Safety of Adapalene, 0.1% (PHASE3)
• Adjunctive Usage of a Moisturizing Lotion (Cetaphil® Moisturizing Lotion) to Limit the Skin Irritation Linked to the Set-Up of a Treatment by Topical Retinoid (Differin® Gel 0,1%) in Healthy Subjects of Chinese Origins (PHASE4)

Primary sources

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