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Corticosteroid 2 - C. propionate
Clobetasol propionate is a potent corticosteroid that suppresses inflammatory and immune responses by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.
Clobetasol propionate is a potent corticosteroid that suppresses inflammatory and immune responses by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production. Used for Severe inflammatory dermatological conditions (e.g., severe psoriasis, lichen planus, severe eczema).
At a glance
| Generic name | Corticosteroid 2 - C. propionate |
|---|---|
| Also known as | Corticosteroid 2 compared to CP Shampoo |
| Sponsor | Galderma R&D |
| Drug class | Corticosteroid (topical, Class I/super-potent) |
| Target | Glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | Phase 3 |
Mechanism of action
Clobetasol propionate is a Class I (super-potent) topical corticosteroid that works by activating intracellular glucocorticoid receptors, leading to decreased production of inflammatory mediators and reduced immune cell infiltration. It is used to treat severe inflammatory skin conditions where rapid anti-inflammatory and immunosuppressive effects are needed.
Approved indications
- Severe inflammatory dermatological conditions (e.g., severe psoriasis, lichen planus, severe eczema)
Common side effects
- Skin atrophy
- Striae
- Telangiectasia
- Local skin irritation
- Systemic corticosteroid absorption (with prolonged use)
Key clinical trials
- Single Blind Cross-over Dose Response Study in Subjects of Two Inhalers of Salmeterol and Fluticasone Propionate (PHASE1)
- Subject Preference for Scalp Psoriasis Treatment (PHASE3)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |