Last reviewed 2026-04-22 · How we verify

Benzoyl Peroxide Gel 2.5%

Benzoyl peroxide kills acne-causing bacteria and promotes skin cell turnover by generating reactive oxygen species.

Benzoyl peroxide kills acne-causing bacteria and promotes skin cell turnover by generating reactive oxygen species. Used for Acne vulgaris.

At a glance

Mechanism of action

Benzoyl peroxide is a bactericidal agent that penetrates the skin and decomposes to produce benzoic acid and oxygen radicals, which are highly effective against Cutibacterium acnes (formerly Propionibacterium acnes). The oxygen radicals disrupt bacterial cell membranes and DNA. Additionally, benzoyl peroxide has mild keratolytic properties that help reduce comedone formation and promote desquamation of skin cells.

Approved indications

• Acne vulgaris

Common side effects

• Skin irritation (erythema, dryness, peeling)
• Contact dermatitis
• Bleaching of hair or fabrics

Key clinical trials

• Experience With Topical Acne Treatment (EARLY_PHASE1)
• Study to Demonstrate the Efficacy and Safety of Adapalene/Benzoyl Peroxide Topical Gel in Subjects With Acne Vulgaris (PHASE3)
• Investigation of the Tolerability of Two Facial Cleansing Routines for Mild to Moderate Acne (PHASE4)
• Long-term Study of Efficacy/Safety of Adapalene/Benzoyl Peroxide Topical Gel in Acne Vulgaris Subjects (PHASE3)
• Pirfenidone Plus M-DDO Gel in Moderate and Severe Acne (PHASE1, PHASE2)
• A Treatment for Severe Inflammatory Acne Subjects (PHASE4)
• A Study of Efficacy of Benzoyl Peroxide Regimens in Treatment of Unpleasant Foot Odor (PHASE4)
• Adapalene 0.3% - Benzoyl Peroxide 2.5% Gel and Risk of Formation of Atrophic Acne Scars (PHASE4)

Primary sources

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