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Loceryl Nail Lacquer
Amorolfine inhibits fungal sterol synthesis by blocking lanosterol demethylase, disrupting the integrity of the fungal cell membrane.
Amorolfine inhibits fungal sterol synthesis by blocking lanosterol demethylase, disrupting the integrity of the fungal cell membrane. Used for Onychomycosis (fungal nail infection) caused by dermatophytes, yeasts, and non-dermatophyte molds.
At a glance
| Generic name | Loceryl Nail Lacquer |
|---|---|
| Also known as | Loceryl NL |
| Sponsor | Galderma R&D |
| Drug class | Morpholine antifungal |
| Target | Lanosterol 14α-demethylase (CYP51) |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | FDA-approved |
Mechanism of action
Amorolfine is a morpholine antifungal that targets the cytochrome P450-dependent enzyme lanosterol 14α-demethylase in the ergosterol synthesis pathway. By inhibiting this enzyme, it causes depletion of ergosterol and accumulation of toxic sterol precursors, leading to fungal cell membrane dysfunction and cell death. This mechanism is effective against dermatophytes, yeasts, and other fungi causing onychomycosis.
Approved indications
- Onychomycosis (fungal nail infection) caused by dermatophytes, yeasts, and non-dermatophyte molds
Common side effects
- Nail discoloration or discoloration at application site
- Periungual erythema
- Burning or irritation at application site
- Rash or contact dermatitis
Key clinical trials
- Antifungal Activity of Loceryl Nail Lacquer in Combination With a Cosmetic Varnish (PHASE4)
- Comparison Between Long-pulsed Nd:YAG, Amorolfine and Combination Treatment in Treating Non-dermatophyte Onychomycosis (PHASE4)
- Treatment of Onychomycosis With Loceryl (Amorolfine) Nail Lacquer 5% Versus Ciclopirox Nail Lacquer (PHASE4)
- Treatment of Onychomycosis With Loceryl (Amorolfine) Nail Lacquer 5% Versus a Two-course Treatment With Urea 40% Ointment and Bifonazole Cream 1% (PHASE4)
- Effectiveness of Podiatry Care on Onychomycosis (EPOCAON) (NA)
- Comparison of Efficacy and Safety Between Methylene Blue-mediated Photodynamic Therapy and 5% Amorolfine Nail Lacquer for Toenail Onychomycosis Treatment (NA)
- Resin vs. Amorolfine vs. Terbinafine Treatment in Onychomycosis (PHASE4)
- A Randomized Study to Evaluate the Efficacy of Herbal Ingredients Combined With a Carrier System (Phytonail) Compared With Amorolfine 5% Nail Lacquer (Loceryl) in the Treatment of Toenail Onychomycosis (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Loceryl Nail Lacquer CI brief — competitive landscape report
- Loceryl Nail Lacquer updates RSS · CI watch RSS
- Galderma R&D portfolio CI