Last reviewed · How we verify
Loceryl NL 12 weeks
Loceryl is a topical antifungal that inhibits fungal sterol synthesis by blocking lanosterol 14α-demethylase, disrupting the fungal cell membrane.
Loceryl is a topical antifungal that inhibits fungal sterol synthesis by blocking lanosterol 14α-demethylase, disrupting the fungal cell membrane. Used for Onychomycosis (fungal nail infection), Dermatophyte and yeast infections of nails.
At a glance
| Generic name | Loceryl NL 12 weeks |
|---|---|
| Sponsor | Galderma R&D |
| Drug class | Allylamine antifungal |
| Target | Lanosterol 14α-demethylase (CYP51) |
| Modality | Small molecule |
| Therapeutic area | Dermatology / Infectious Disease |
| Phase | FDA-approved |
Mechanism of action
Amorolfine, the active ingredient in Loceryl, is an allylamine antifungal that interferes with ergosterol biosynthesis in fungal cell membranes. By inhibiting the cytochrome P450-dependent enzyme lanosterol 14α-demethylase, it causes accumulation of toxic sterol precursors and depletion of ergosterol, leading to fungal cell death. This mechanism makes it effective against dermatophytes, yeasts, and non-dermatophyte molds.
Approved indications
- Onychomycosis (fungal nail infection)
- Dermatophyte and yeast infections of nails
Common side effects
- Local irritation or burning at application site
- Nail discoloration or discomfort
- Allergic contact dermatitis
Key clinical trials
- Antifungal Activity of Loceryl Nail Lacquer in Combination With a Cosmetic Varnish (PHASE4)
- Treatment of Onychomycosis With Loceryl (Amorolfine) Nail Lacquer 5% Versus Ciclopirox Nail Lacquer (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |