{"id":"loceryl-nl-12-weeks","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or burning at application site"},{"rate":null,"effect":"Nail discoloration or discomfort"},{"rate":null,"effect":"Allergic contact dermatitis"}]},"_chembl":{"chemblId":"CHEMBL1668639","moleculeType":"Small molecule","molecularWeight":"682.71"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Amorolfine, the active ingredient in Loceryl, is an allylamine antifungal that interferes with ergosterol biosynthesis in fungal cell membranes. By inhibiting the cytochrome P450-dependent enzyme lanosterol 14α-demethylase, it causes accumulation of toxic sterol precursors and depletion of ergosterol, leading to fungal cell death. This mechanism makes it effective against dermatophytes, yeasts, and non-dermatophyte molds.","oneSentence":"Loceryl is a topical antifungal that inhibits fungal sterol synthesis by blocking lanosterol 14α-demethylase, disrupting the fungal cell membrane.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:52:43.988Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Onychomycosis (fungal nail infection)"},{"name":"Dermatophyte and yeast infections of nails"}]},"trialDetails":[{"nctId":"NCT02321098","phase":"PHASE4","title":"Antifungal Activity of Loceryl Nail Lacquer in Combination With a Cosmetic Varnish","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2014-02","conditions":"Foot Dermatoses","enrollment":50},{"nctId":"NCT02679911","phase":"PHASE4","title":"Treatment of Onychomycosis With Loceryl (Amorolfine) Nail Lacquer 5% Versus Ciclopirox Nail Lacquer","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2015-09","conditions":"Foot Dermatoses","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Loceryl NL 12 weeks","genericName":"Loceryl NL 12 weeks","companyName":"Galderma R&D","companyId":"galderma-r-d","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Loceryl is a topical antifungal that inhibits fungal sterol synthesis by blocking lanosterol 14α-demethylase, disrupting the fungal cell membrane. Used for Onychomycosis (fungal nail infection), Dermatophyte and yeast infections of nails.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}