Last reviewed · How we verify

Metronidazole gel 1%

Galderma R&D · FDA-approved active Small molecule

Metronidazole gel 1% is a Nitroimidazole antimicrobial Small molecule drug developed by Galderma R&D. It is currently FDA-approved for Rosacea (topical), Bacterial vaginosis (topical), Perioral dermatitis (topical). Also known as: MetroGel® 1%, MetroGel® 1% gel.

Metronidazole disrupts bacterial and protozoal DNA by generating reactive oxygen species and damaging nucleic acids, leading to cell death.

Metronidazole disrupts bacterial and protozoal DNA by generating reactive oxygen species, leading to cell death. Used for Rosacea (topical), Bacterial vaginosis (topical), Perioral dermatitis (topical).

At a glance

Generic nameMetronidazole gel 1%
Also known asMetroGel® 1%, MetroGel® 1% gel
SponsorGalderma R&D
Drug classNitroimidazole antimicrobial
TargetBacterial/protozoal DNA
ModalitySmall molecule
Therapeutic areaDermatology
PhaseFDA-approved

Mechanism of action

Metronidazole is a prodrug that is activated by anaerobic organisms and protozoans to form reactive intermediates that bind to and damage DNA, preventing replication and transcription. This mechanism is particularly effective against anaerobic bacteria and certain parasites. The topical gel formulation delivers the drug directly to affected skin areas, minimizing systemic absorption.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

Frequently asked questions about Metronidazole gel 1%

What is Metronidazole gel 1%?

Metronidazole gel 1% is a Nitroimidazole antimicrobial drug developed by Galderma R&D, indicated for Rosacea (topical), Bacterial vaginosis (topical), Perioral dermatitis (topical).

How does Metronidazole gel 1% work?

Metronidazole disrupts bacterial and protozoal DNA by generating reactive oxygen species and damaging nucleic acids, leading to cell death.

What is Metronidazole gel 1% used for?

Metronidazole gel 1% is indicated for Rosacea (topical), Bacterial vaginosis (topical), Perioral dermatitis (topical).

Who makes Metronidazole gel 1%?

Metronidazole gel 1% is developed and marketed by Galderma R&D (see full Galderma R&D pipeline at /company/galderma-r-d).

Is Metronidazole gel 1% also known as anything else?

Metronidazole gel 1% is also known as MetroGel® 1%, MetroGel® 1% gel.

What drug class is Metronidazole gel 1% in?

Metronidazole gel 1% belongs to the Nitroimidazole antimicrobial class. See all Nitroimidazole antimicrobial drugs at /class/nitroimidazole-antimicrobial.

What development phase is Metronidazole gel 1% in?

Metronidazole gel 1% is FDA-approved (marketed).

What are the side effects of Metronidazole gel 1%?

Common side effects of Metronidazole gel 1% include Local irritation or burning at application site, Dryness or peeling, Metallic taste (if absorbed systemically).

What does Metronidazole gel 1% target?

Metronidazole gel 1% targets Bacterial/protozoal DNA and is a Nitroimidazole antimicrobial.

Related