NMDA receptor — Drug Target

All drugs that target NMDA receptor — marketed and clinical-stage. Includes 13 drug classes acting on this target.

Drug classes

NMDA receptor antagonist · Dissociative anesthetic · Inhalational anesthetic · NMDA receptor antagonist combination · NMDA receptor antagonist (dissociative anesthetic) · Anesthetic · NMDA receptor antagonist / Dissociative anesthetic · anesthetic · General anesthetic · NMDA receptor antagonist / Anticonvulsant · NMDA receptor antagonist / Neuroprotective agent · Neuroprotective agent

Marketed (32)

• Ketamine plus usual care · The University of Texas Health Science Center, Houston · NMDA receptor antagonist · Anesthesia, Pain Management
  Ketamine blocks NMDA glutamate receptors in the brain, producing rapid-onset dissociative anesthesia and analgesic effects.
• Ketamine perfusion · University Tunis El Manar · Dissociative anesthetic · Neuroscience
• PCA Ketamine · Universidad de Antioquia · NMDA receptor antagonist · Anesthesia
  PCA Ketamine is a patient-controlled anesthesia formulation of ketamine that acts as an NMDA receptor antagonist to produce dissociative anesthesia and analgesia.
• Nitrous Oxide 99 % · Unity Health Toronto · Inhalational anesthetic · Anesthesia
  Nitrous oxide acts as a dissociative anesthetic and analgesic by antagonizing N-methyl-D-aspartate (NMDA) receptors in the central nervous system.
• S (+) Ketamine · Asker & Baerum Hospital · NMDA receptor antagonist · Anesthesia, Pain Management, Psychiatry
  S(+) ketamine is an NMDA receptor antagonist that blocks glutamate signaling in the brain, producing rapid-onset anesthetic and analgesic effects.
• S-Ketamine 0.5 · Turku University Hospital · NMDA receptor antagonist · Anesthesia; Psychiatry
  S-Ketamine is the active S-enantiomer of ketamine that acts as a non-competitive antagonist at the NMDA receptor, blocking glutamate signaling in the central nervous system.
• Intra-nasal ketamine · Lions Gate Hospital · NMDA receptor antagonist · Psychiatry, Pain Management, Anesthesia
  Intranasal ketamine is a non-competitive NMDA receptor antagonist that rapidly blocks glutamate signaling in the brain to produce dissociative and analgesic effects.
• Ketamine + magnesium · University of Chile · NMDA receptor antagonist combination · Psychiatry, Pain Management
  Ketamine blocks NMDA receptors while magnesium enhances this blockade and stabilizes the drug's effects, together producing rapid-onset antidepressant and analgesic effects.
• Procedural sedation with ketamine alone · Centre Hospitalier Universitaire de Nice · NMDA receptor antagonist · Anesthesia/Procedural Sedation
  Ketamine is a non-competitive NMDA receptor antagonist that produces rapid-onset dissociative sedation and analgesia suitable for procedural use.
• Ketamine (1st phase) · Shalvata Mental Health Center · NMDA receptor antagonist · Psychiatry / Mental Health
  Ketamine is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor that blocks glutamate signaling in the brain.
• Ketamine Injectable Product · Hackensack Meridian Health · NMDA receptor antagonist · Anesthesia, Pain Management, Psychiatry
  Ketamine is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor that blocks glutamate signaling in the central nervous system.
• ketamine 1.5 · Ajou University School of Medicine · NMDA receptor antagonist · Anesthesia, Pain Management, Psychiatry
  Ketamine is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor that blocks glutamate signaling in the central nervous system.
• Ketamine and Magnesium Sulfate · Ain Shams University · NMDA receptor antagonist combination · Anesthesia, Pain Management
  Ketamine acts as an NMDA receptor antagonist while magnesium sulfate enhances NMDA receptor blockade and provides neuroprotection, together reducing pain and providing anesthesia.
• Ketamine (2st phase) · Shalvata Mental Health Center · NMDA receptor antagonist · Psychiatry, Anesthesia, Pain Management
  Ketamine is a non-competitive NMDA receptor antagonist that blocks glutamate signaling in the brain, producing rapid-onset dissociative anesthesia and analgesic effects.
• S-Ketamine 0.75 · Turku University Hospital · NMDA receptor antagonist · Anesthesia
  S-Ketamine is the active S-enantiomer of ketamine that acts as a non-competitive antagonist at the N-methyl-D-aspartate (NMDA) receptor to produce rapid-onset anesthetic and analgesic effects.
• Memantine (twice daily) · H. Lundbeck A/S · NMDA receptor antagonist · Neurology
  Memantine is an uncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor that blocks excessive glutamate signaling in the brain.
• N2O gas vs ketamine · Seoul National University Hospital · NMDA receptor antagonist (dissociative anesthetic) · Anesthesia / Analgesia
  This is a comparative study of two dissociative anesthetics—nitrous oxide (N2O) and ketamine—which work by blocking NMDA receptors to produce anesthesia and analgesia.
• Memantine Oral Tablet · First Affiliated Hospital Xi'an Jiaotong University · NMDA receptor antagonist · Neurology
  Memantine is an uncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor that reduces excessive glutamatergic neurotransmission in the brain.
• Ketamine load · University of Pennsylvania · NMDA receptor antagonist · Anesthesia; Psychiatry (depression)
  Ketamine is an NMDA receptor antagonist that blocks glutamate signaling in the brain, producing rapid-onset anesthetic and dissociative effects.
• Nitrous oxide gas for inhalation · Unity Health Toronto · Dissociative anesthetic · Anesthesia and Acute Pain Management
  Nitrous oxide acts as a dissociative anesthetic and analgesic by modulating NMDA receptor activity and enhancing inhibitory neurotransmission in the central nervous system.
• bolus of intravenous ketamine · Ciusss de L'Est de l'Île de Montréal · NMDA receptor antagonist · Anesthesia, Analgesia, Psychiatry
  Ketamine is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor that produces rapid-onset anesthesia and analgesia.
• Intraoperative infusion of esketamine · Nanjing First Hospital, Nanjing Medical University · NMDA receptor antagonist · Anesthesia
  Esketamine is an NMDA receptor antagonist that blocks glutamate signaling in the central nervous system, providing rapid-onset anesthesia and analgesia during surgical procedures.
• Memantine Hydrochloride Tablets · University of Virginia · NMDA receptor antagonist · Neurology
  Memantine is an uncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor that reduces excessive glutamate-mediated neuronal excitotoxicity.
• Memantine (Namenda®) · Washington University School of Medicine · NMDA receptor antagonist · Neurology
  Memantine is an uncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor that blocks excessive glutamate signaling in the brain.
• S-Ketamine 0.25 · Turku University Hospital · NMDA receptor antagonist · Anesthesia, Pain Management, Psychiatry
  S-Ketamine is an NMDA receptor antagonist that blocks glutamate signaling in the brain, producing rapid-onset anesthetic and analgesic effects.
• Ketamine IV push · Alameda Health System · NMDA receptor antagonist · Anesthesia, Pain Management, Psychiatry
  Ketamine is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor that produces rapid-onset anesthesia and analgesia.
• Esketamine Nasal Spray [Spravato] · Royal North Shore Hospital · NMDA receptor antagonist · Psychiatry
  Esketamine is an NMDA receptor antagonist that rapidly blocks glutamate signaling in the brain to produce fast-acting antidepressant effects.
• continuous infusion of intravenous ketamine · Ciusss de L'Est de l'Île de Montréal · NMDA receptor antagonist · Anesthesia, Pain Management, Psychiatry
  Ketamine is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor that blocks glutamate signaling in the central nervous system.
• Oral ketamine · Universidade Federal de Goias · NMDA receptor antagonist · Psychiatry, Pain Management, Anesthesia
  Ketamine is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor that blocks glutamate signaling in the central nervous system.
• Intranasal ketamine · Rhode Island Hospital · NMDA receptor antagonist · Psychiatry / Pain Management
  Intranasal ketamine is a rapid-acting NMDA receptor antagonist that blocks glutamate signaling in the brain to produce fast-onset antidepressant and analgesic effects.
• Memantine (once daily) · H. Lundbeck A/S · NMDA receptor antagonist · Neurology
  Memantine is an uncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor that reduces excessive glutamate-mediated neuronal excitotoxicity.
• esketamine group · Beijing Tiantan Hospital · NMDA receptor antagonist · Psychiatry
  Esketamine is an NMDA receptor antagonist that rapidly blocks glutamate signaling in the brain to produce fast-acting antidepressant effects.

Phase 3 pipeline (24)

• Fasedienol Nasal Spray · VistaGen Therapeutics, Inc. · NMDA receptor antagonist · Psychiatry / Neurology
  Fasedienol is a NMDA receptor antagonist administered as a nasal spray for rapid-onset treatment of depression.
• combination of Ketamine and Propofol · Nantes University Hospital · Anesthetic · Anesthesiology
  Ketamine and Propofol work together to induce general anesthesia by modulating NMDA receptors and inhibiting GABA uptake.
• CI-581-a · New York State Psychiatric Institute · NMDA receptor antagonist / Dissociative anesthetic · Anesthesia / Psychiatry
  CI-581-a is a dissociative anesthetic that acts as an NMDA receptor antagonist to produce rapid-onset anesthesia and analgesia.
• Ketamine plus magnesium group · National Cancer Institute, Egypt · NMDA receptor antagonist combination · Oncology
  Ketamine blocks NMDA receptors while magnesium enhances this antagonism and may provide neuroprotective and anti-inflammatory effects.
• Memantine (Ebixa) · University of Lisbon · NMDA receptor antagonist · Neurology
  Memantine is an uncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor that blocks excessive glutamate signaling in the brain.
• nebulized ketamine · Theresa Jacob, PhD, MPH · anesthetic · Pain management
  Nebulized ketamine works by blocking NMDA receptors in the brain, which can help reduce inflammation and pain.
• Esketamine Nasal Product · Dr. Inge Winter · NMDA receptor antagonist · Psychiatry / Neurology
  Esketamine is an NMDA receptor antagonist that rapidly blocks glutamate signaling in the brain to produce fast-acting antidepressant effects.
• CI-581-b · New York State Psychiatric Institute · NMDA receptor antagonist / Dissociative anesthetic · Anesthesia / Psychiatry
  CI-581-b is a dissociative anesthetic that acts as an NMDA receptor antagonist to produce rapid-onset anesthesia and analgesia.
• CI-581a · New York State Psychiatric Institute · NMDA receptor antagonist · Anesthesia
  CI-581a is a dissociative anesthetic that acts as an NMDA receptor antagonist to produce rapid-onset anesthesia and analgesia.
• IM Ketamine · Tel-Aviv Sourasky Medical Center · NMDA receptor antagonist · Psychiatry / Pain Management
  IM Ketamine is an N-methyl-D-aspartate (NMDA) receptor antagonist administered intramuscularly that produces rapid-onset dissociative anesthesia and analgesia.
• IN ketamine · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · NMDA receptor antagonist · Psychiatry / Pain Management
  Intranasal ketamine is a rapid-acting NMDA receptor antagonist that blocks glutamate signaling in the brain to produce fast-onset antidepressant and analgesic effects.
• Xenon vs propofol · Rigshospitalet, Denmark · General anesthetic · Anesthesiology
  Xenon is a general anesthetic that works by modulating the activity of N-methyl-D-aspartate (NMDA) receptors in the brain.
• ketamine sedation versus midazolam sedation · Universidad de Colima · Anesthetic · Anesthesiology
  Ketamine acts as an NMDA receptor antagonist, blocking the action of glutamate in the brain.
• Magnesium Sulfate high dose · Dr Olu Bamgbade, MD, FRCPC · NMDA receptor antagonist / Anticonvulsant · Neurology
  High-dose magnesium sulfate acts as a NMDA receptor antagonist and stabilizes neuronal membranes, reducing excitotoxicity and seizure activity.
• Namenda/Memantine · State University of New York - Upstate Medical University · NMDA receptor antagonist · Neurology
  Memantine is an uncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor that blocks excessive glutamate signaling in the brain.
• CI-581b · New York State Psychiatric Institute · NMDA receptor antagonist · Psychiatry
  CI-581b is a dissociative anesthetic that acts as an NMDA receptor antagonist to produce rapid-onset antidepressant effects.
• Hi-dose iv MgSO4 · Hamad Medical Corporation · NMDA receptor antagonist / Neuroprotective agent · Neurology
  High-dose intravenous magnesium sulfate acts as a neuroprotective agent and anticonvulsant by blocking N-methyl-D-aspartate (NMDA) receptors and stabilizing neuronal membranes.
• Sedation by ketamine · University Hospital, Montpellier · Anesthetic · Anesthesiology
  Ketamine acts as an NMDA receptor antagonist, blocking the action of glutamate at the NMDA receptor.
• Xaliproden (SR57746A) · Sanofi · Neuroprotective agent · Neurology
  Xaliproden acts as a neuroprotective agent by modulating the activity of the NMDA receptor.
• glutamate infusion · University Hospital, Linkoeping · Neurology
  Glutamate infusion works by increasing the concentration of glutamate in the brain, which can help to stimulate neural activity and improve cognitive function.
• IV Ketamine · Icahn School of Medicine at Mount Sinai · NMDA receptor antagonist · Psychiatry / Pain Management
  IV ketamine is an NMDA receptor antagonist that blocks glutamate signaling in the brain, producing rapid-onset dissociative and analgesic effects.
• nefopam, ketoprofen, paracetamol · American University of Beirut Medical Center · NMDA receptor antagonist · Pain management
  Nefopam is a non-opioid analgesic that acts as an NMDA receptor antagonist, inhibiting the release of pain-producing neurotransmitters.
• AM-101 · Auris Medical AG · NMDA receptor antagonist · Otolaryngology / Neurology
  AM-101 is an intratympanic injection that delivers a small-molecule NMDA receptor antagonist to the inner ear to reduce tinnitus perception.
• Memantine-XR · University of North Carolina, Chapel Hill · NMDA receptor antagonist · Neurology
  Memantine-XR is an extended-release formulation of memantine, an uncompetitive NMDA receptor antagonist that blocks excessive glutamate signaling in the brain.

Phase 2 pipeline (6)

• Esketamine DPI - low dose · Celon Pharma SA · NMDA receptor antagonist · Psychiatry / Neurology
  Esketamine is an NMDA receptor antagonist that blocks glutamate signaling in the brain, with rapid-acting antidepressant effects.
• Analgesic Non Narcotic · Cali Pharmaceuticals LLC · Non-narcotic analgesic · Oncology
  Blocks NMDA receptors to reduce pain perception
• Augment with Memantine · Shanghai Mental Health Center · NMDA receptor antagonist · Neurology
  Augment with Memantine is a combination of a glutamate receptor antagonist and a NMDA receptor antagonist, which may help to improve cognitive function in patients with Alzheimer's disease.
• APD403 IV · Acacia Pharma Ltd · NMDA receptor antagonist · Anesthesiology
  APD403 IV is an anesthetic agent that works by blocking N-methyl-D-aspartate (NMDA) receptors.
• Ketamine 10% · Express Specialty Pharmacy · Anesthetic · Anesthesiology
  NMDA receptor antagonist
• AZD6765 iv · AstraZeneca · NMDA receptor antagonist · Psychiatry
  AZD6765 is an NMDA receptor antagonist that modulates glutamatergic neurotransmission to produce rapid-acting antidepressant effects.