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Ketamine and Magnesium Sulfate
Ketamine acts as an NMDA receptor antagonist while magnesium sulfate enhances NMDA receptor blockade and provides neuroprotection, together reducing pain and providing anesthesia.
Ketamine acts as an NMDA receptor antagonist while magnesium sulfate enhances NMDA receptor blockade and provides neuroprotection, together reducing pain and providing anesthesia. Used for Anesthesia induction and maintenance, Acute pain management, Perioperative analgesia.
At a glance
| Generic name | Ketamine and Magnesium Sulfate |
|---|---|
| Sponsor | Ain Shams University |
| Drug class | NMDA receptor antagonist combination |
| Target | NMDA receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia, Pain Management |
| Phase | FDA-approved |
Mechanism of action
Ketamine is a non-competitive antagonist at the N-methyl-D-aspartate (NMDA) receptor, blocking glutamate-mediated excitatory neurotransmission and producing dissociative anesthesia and analgesia. Magnesium sulfate potentiates this effect by acting as a natural NMDA receptor antagonist and provides additional neuroprotective and anti-inflammatory benefits. This combination is used to enhance anesthetic and analgesic efficacy while potentially reducing required ketamine doses.
Approved indications
- Anesthesia induction and maintenance
- Acute pain management
- Perioperative analgesia
Common side effects
- Dissociation
- Dizziness
- Nausea
- Hypertension
- Tachycardia
- Emergence reactions
Key clinical trials
- Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery
- Magnesium Sulfate Versus Other Anesthesia Drugs to Reduce Agitation After Adenotonsillectomy in Pediatric Patients (NA)
- Ketamine Versus Magnesium Sulphate as Adjuvants for ESPB in Breast Cancer Surgery (PHASE2)
- Intravenous Lidocaine, Ketamine, and Magnesium in Thoracic Surgery
- COMPARISON OF OPIOID-FREE AND OPIOID-BASED ANESTHESIA TECHNIQUES ON qNOX INDEX IN ABDOMINAL SURGERY UNDER GENERAL ANESTHESIA (NA)
- The Efface of Lidocaine vs. Magnesium Sulphate in the Management of Pain After Laparoscopic Cholecystectomy (PHASE1)
- The Efface of Ketamine vs. Magnesium Sulphate in the Management of Pain After Laparoscopic Cholecystectomy (PHASE1)
- Anesthesia Techniques, Neuroprotection and Surgical Field in FESS Under Controlled Hypotension (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ketamine and Magnesium Sulfate CI brief — competitive landscape report
- Ketamine and Magnesium Sulfate updates RSS · CI watch RSS
- Ain Shams University portfolio CI