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PCA Ketamine
PCA Ketamine is a patient-controlled anesthesia formulation of ketamine that acts as an NMDA receptor antagonist to produce dissociative anesthesia and analgesia.
PCA Ketamine is a patient-controlled anesthesia formulation of ketamine that acts as an NMDA receptor antagonist to produce dissociative anesthesia and analgesia. Used for Anesthesia induction and maintenance, Acute pain management in perioperative settings.
At a glance
| Generic name | PCA Ketamine |
|---|---|
| Also known as | Ketamine PCA |
| Sponsor | Universidad de Antioquia |
| Drug class | NMDA receptor antagonist |
| Target | NMDA receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Ketamine blocks N-methyl-D-aspartate (NMDA) receptors on glutamatergic neurons, interrupting pain signal transmission and producing rapid-onset dissociative anesthesia. The PCA (patient-controlled anesthesia) delivery system allows patients to self-administer doses within programmed safety limits, providing on-demand analgesia and sedation. This formulation is used in clinical settings where patient-controlled dosing of ketamine's anesthetic and analgesic properties is therapeutically beneficial.
Approved indications
- Anesthesia induction and maintenance
- Acute pain management in perioperative settings
Common side effects
- Dissociation/emergence reactions
- Hypertension
- Tachycardia
- Nausea/vomiting
- Dizziness
Key clinical trials
- Examining Analgesic Synergy and Efficacy in Trauma Care (PHASE4)
- Small Study Comparing Two Pain Medicines in Teenagers for Pain Control After Scoliosis Corrective Surgery. (NA)
- Ketamine Administration for Postoperative Pain Management in Patients Undergoing Knee Arthroplasty (NA)
- Perioperative Opioid-induced Hyperalgesia and Its Prevention With Ketamine and Methadone (NA)
- Serratus Posterior Superior Plane Block for Postoperative Pain in Cardiac Surgery (NA)
- Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correction Surgery (PHASE4)
- Mini-dose Esketamine-dexmedetomidine Supplemented Analgesia and Long-term Outcomes (PHASE4)
- Different Dose Esketamine and Dexmedetomidine for Supplemental Analgesia and Longterm Outcomes (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- PCA Ketamine CI brief — competitive landscape report
- PCA Ketamine updates RSS · CI watch RSS
- Universidad de Antioquia portfolio CI