{"id":"pca-ketamine","safety":{"commonSideEffects":[{"rate":null,"effect":"Dissociation/emergence reactions"},{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Nausea/vomiting"},{"rate":null,"effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ketamine blocks N-methyl-D-aspartate (NMDA) receptors on glutamatergic neurons, interrupting pain signal transmission and producing rapid-onset dissociative anesthesia. The PCA (patient-controlled anesthesia) delivery system allows patients to self-administer doses within programmed safety limits, providing on-demand analgesia and sedation. This formulation is used in clinical settings where patient-controlled dosing of ketamine's anesthetic and analgesic properties is therapeutically beneficial.","oneSentence":"PCA Ketamine is a patient-controlled anesthesia formulation of ketamine that acts as an NMDA receptor antagonist to produce dissociative anesthesia and analgesia.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:59:59.787Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Anesthesia induction and maintenance"},{"name":"Acute pain management in perioperative settings"}]},"trialDetails":[{"nctId":"NCT07435077","phase":"PHASE4","title":"Examining Analgesic Synergy and Efficacy in Trauma Care","status":"NOT_YET_RECRUITING","sponsor":"Wake Forest University Health Sciences","startDate":"2026-05","conditions":"Opioid Use Disorder","enrollment":282},{"nctId":"NCT07452705","phase":"NA","title":"Small Study Comparing Two Pain Medicines in Teenagers for Pain Control After Scoliosis Corrective Surgery.","status":"NOT_YET_RECRUITING","sponsor":"University of Malaya","startDate":"2026-02-02","conditions":"Adolescent Idiopathic Scoliosis (AIS)","enrollment":114},{"nctId":"NCT07059429","phase":"NA","title":"Ketamine Administration for Postoperative Pain Management in Patients Undergoing Knee Arthroplasty","status":"COMPLETED","sponsor":"State Budgetary Healthcare Institution, National Medical Surgical Center N.A. 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