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Ketamine 10%
NMDA receptor antagonist
NMDA receptor antagonist Used for General anesthesia.
At a glance
| Generic name | Ketamine 10% |
|---|---|
| Also known as | Ketamine |
| Sponsor | Express Specialty Pharmacy |
| Drug class | Anesthetic |
| Target | NMDA receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | Phase 2 |
Mechanism of action
Ketamine acts as a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, a subtype of glutamate receptor, which is involved in synaptic plasticity and memory formation.
Approved indications
- General anesthesia
Common side effects
- Dissociation
- Hallucinations
- Increased heart rate
Key clinical trials
- Electroencephalographic (EEG) Profils for Patients on Intravenous Ketamine.
- The Impact of a Shared Decision-Making Intervention on Intraoperative Patient Experience During Elective Cesarean Delivery Under Spinal Anesthesia (NA)
- Ketamine-lidocaine Versus Ketamine-fentanyl for Induction of Anesthesia in Patients With Left Ventricular Systolic Dysfunction Undergoing Elective Coronary Artery Bypass (NA)
- Premedication in Children: a Clinical Trial Comparing Oral Ketamine and Oral Clonidine With Respect to Sedation Level and Opioid Consumption in Pediatrics Undergoing Elective Lower Abdominal Day-case Surgery. (NA)
- KF2025#1 Trial: Ketamine, Cannabidiol and Cobicistat Interaction Study (PHASE1)
- Prospective IR-led Sedation Feasibility (PHASE1, PHASE2)
- Comparative Assessment of Oral Premedication Regimens in Pediatric Ambulatory Surgery (NA)
- Ketamine Administration for Postoperative Pain Management in Patients Undergoing Knee Arthroplasty (NA)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |