NMDA receptor antagonist combination

This page covers all NMDA receptor antagonist combination drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting NMDA receptor, NMDA receptor, sigma-1 receptor.

Targets

NMDA receptor · NMDA receptor, sigma-1 receptor

Marketed (2)

• Ketamine + magnesium · University of Chile · Psychiatry, Pain Management
  Ketamine blocks NMDA receptors while magnesium enhances this blockade and stabilizes the drug's effects, together producing rapid-onset antidepressant and analgesic effects.
• Ketamine and Magnesium Sulfate · Ain Shams University · Anesthesia, Pain Management
  Ketamine acts as an NMDA receptor antagonist while magnesium sulfate enhances NMDA receptor blockade and provides neuroprotection, together reducing pain and providing anesthesia.

Phase 3 pipeline (2)

• Ketamine plus magnesium group · National Cancer Institute, Egypt · Oncology
  Ketamine blocks NMDA receptors while magnesium enhances this antagonism and may provide neuroprotective and anti-inflammatory effects.
• dextromethorphan+memantine · National Cheng-Kung University Hospital · Neurology
  This combination blocks NMDA receptors (memantine) and inhibits reuptake of norepinephrine and serotonin (dextromethorphan) to modulate neuropathic pain and neurological symptoms.