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Ketamine + magnesium
Ketamine + magnesium is a NMDA receptor antagonist combination Small molecule drug developed by University of Chile. It is currently FDA-approved for Treatment-resistant depression, Acute suicidality, Chronic pain conditions. Also known as: ketalar + Magnesium Sulfate.
Ketamine blocks NMDA receptors while magnesium enhances this blockade and stabilizes the drug's effects, together producing rapid-onset antidepressant and analgesic effects.
Ketamine blocks NMDA receptors while magnesium enhances this blockade and stabilizes the drug's effects, together producing rapid-onset antidepressant and analgesic effects. Used for Treatment-resistant depression, Acute suicidality, Chronic pain conditions.
At a glance
| Generic name | Ketamine + magnesium |
|---|---|
| Also known as | ketalar + Magnesium Sulfate |
| Sponsor | University of Chile |
| Drug class | NMDA receptor antagonist combination |
| Target | NMDA receptor |
| Modality | Small molecule |
| Therapeutic area | Psychiatry, Pain Management |
| Phase | FDA-approved |
Mechanism of action
Ketamine is a non-competitive NMDA receptor antagonist that produces dissociative anesthesia and has been shown to have rapid antidepressant properties. Magnesium acts as a natural NMDA receptor antagonist and may potentiate ketamine's effects while potentially reducing dissociative side effects and improving tolerability. The combination is hypothesized to provide synergistic neuroprotection and faster therapeutic onset.
Approved indications
- Treatment-resistant depression
- Acute suicidality
- Chronic pain conditions
Common side effects
- Dissociation
- Dizziness
- Nausea
- Increased blood pressure
- Sedation
Key clinical trials
- Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery
- Magnesium Sulfate Versus Other Anesthesia Drugs to Reduce Agitation After Adenotonsillectomy in Pediatric Patients (NA)
- Ketamine Versus Magnesium Sulphate as Adjuvants for ESPB in Breast Cancer Surgery (PHASE2)
- Comparison of Nebulized Ketamine With Nebulized Magnesium Sulfate for the Prevention of Postoperative Sore Throat (NA)
- Intravenous Lidocaine, Ketamine, and Magnesium in Thoracic Surgery
- COMPARISON OF OPIOID-FREE AND OPIOID-BASED ANESTHESIA TECHNIQUES ON qNOX INDEX IN ABDOMINAL SURGERY UNDER GENERAL ANESTHESIA (NA)
- The Efface of Lidocaine vs. Magnesium Sulphate in the Management of Pain After Laparoscopic Cholecystectomy (PHASE1)
- The Efface of Ketamine vs. Magnesium Sulphate in the Management of Pain After Laparoscopic Cholecystectomy (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ketamine + magnesium CI brief — competitive landscape report
- Ketamine + magnesium updates RSS · CI watch RSS
- University of Chile portfolio CI
Frequently asked questions about Ketamine + magnesium
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Related
- Drug class: All NMDA receptor antagonist combination drugs
- Target: All drugs targeting NMDA receptor
- Manufacturer: University of Chile — full pipeline
- Therapeutic area: All drugs in Psychiatry, Pain Management
- Indication: Drugs for Treatment-resistant depression
- Indication: Drugs for Acute suicidality
- Indication: Drugs for Chronic pain conditions
- Also known as: ketalar + Magnesium Sulfate
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing