NMDA receptor antagonist
This page covers all NMDA receptor antagonist drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting NMDA receptor, NMDA receptor (N-methyl-D-aspartate receptor), NMDA receptor (glutamate-gated ion channel).
Targets
NMDA receptor · NMDA receptor (N-methyl-D-aspartate receptor) · NMDA receptor (glutamate-gated ion channel) · NMDA receptor (glutamate receptor)
Marketed (28)
- Ketamine load · University of Pennsylvania · Anesthesia; Psychiatry (depression)
Ketamine is an NMDA receptor antagonist that blocks glutamate signaling in the brain, producing rapid-onset anesthetic and dissociative effects. - Ketamine (1st phase) · Shalvata Mental Health Center · Psychiatry / Mental Health
Ketamine is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor that blocks glutamate signaling in the brain. - Ketamine IV push · Alameda Health System · Anesthesia, Pain Management, Psychiatry
Ketamine is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor that produces rapid-onset anesthesia and analgesia. - ketamine 1.5 · Ajou University School of Medicine · Anesthesia, Pain Management, Psychiatry
Ketamine is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor that blocks glutamate signaling in the central nervous system. - S (+) Ketamine · Asker & Baerum Hospital · Anesthesia, Pain Management, Psychiatry
S(+) ketamine is an NMDA receptor antagonist that blocks glutamate signaling in the brain, producing rapid-onset anesthetic and analgesic effects. - Ketamine (2st phase) · Shalvata Mental Health Center · Psychiatry, Anesthesia, Pain Management
Ketamine is a non-competitive NMDA receptor antagonist that blocks glutamate signaling in the brain, producing rapid-onset dissociative anesthesia and analgesic effects. - Memantine (twice daily) · H. Lundbeck A/S · Neurology
Memantine is an uncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor that blocks excessive glutamate signaling in the brain. - Procedural sedation with ketamine alone · Centre Hospitalier Universitaire de Nice · Anesthesia/Procedural Sedation
Ketamine is a non-competitive NMDA receptor antagonist that produces rapid-onset dissociative sedation and analgesia suitable for procedural use. - esketamine group · Beijing Tiantan Hospital · Psychiatry
Esketamine is an NMDA receptor antagonist that rapidly blocks glutamate signaling in the brain to produce fast-acting antidepressant effects. - bolus of intravenous ketamine · Ciusss de L'Est de l'Île de Montréal · Anesthesia, Analgesia, Psychiatry
Ketamine is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor that produces rapid-onset anesthesia and analgesia. - S-Ketamine 0.25 · Turku University Hospital · Anesthesia, Pain Management, Psychiatry
S-Ketamine is an NMDA receptor antagonist that blocks glutamate signaling in the brain, producing rapid-onset anesthetic and analgesic effects. - Ketamine plus usual care · The University of Texas Health Science Center, Houston · Anesthesia, Pain Management
Ketamine blocks NMDA glutamate receptors in the brain, producing rapid-onset dissociative anesthesia and analgesic effects. - Intravenous Esketamine · Janssen Research & Development, LLC · Psychiatry / Mental Health
Intravenous esketamine is an NMDA receptor antagonist that rapidly blocks glutamate signaling in the brain to produce fast-acting antidepressant effects. - Memantine Oral Tablet · First Affiliated Hospital Xi'an Jiaotong University · Neurology
Memantine is an uncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor that reduces excessive glutamatergic neurotransmission in the brain. - S-Ketamine 0.75 · Turku University Hospital · Anesthesia
S-Ketamine is the active S-enantiomer of ketamine that acts as a non-competitive antagonist at the N-methyl-D-aspartate (NMDA) receptor to produce rapid-onset anesthetic and analgesic effects. - Esketamine Nasal Spray [Spravato] · Royal North Shore Hospital · Psychiatry
Esketamine is an NMDA receptor antagonist that rapidly blocks glutamate signaling in the brain to produce fast-acting antidepressant effects. - continuous infusion of intravenous ketamine · Ciusss de L'Est de l'Île de Montréal · Anesthesia, Pain Management, Psychiatry
Ketamine is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor that blocks glutamate signaling in the central nervous system. - Oral ketamine · Universidade Federal de Goias · Psychiatry, Pain Management, Anesthesia
Ketamine is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor that blocks glutamate signaling in the central nervous system. - dexter ketamine · Federal University of São Paulo · Psychiatry / Anesthesia
Dexketamine (the active S-enantiomer of ketamine) blocks NMDA glutamate receptors in the central nervous system to produce rapid-acting antidepressant and anesthetic effects. - PCA Ketamine · Universidad de Antioquia · Anesthesia
PCA Ketamine is a patient-controlled anesthesia formulation of ketamine that acts as an NMDA receptor antagonist to produce dissociative anesthesia and analgesia. - S-Ketamine 0.5 · Turku University Hospital · Anesthesia; Psychiatry
S-Ketamine is the active S-enantiomer of ketamine that acts as a non-competitive antagonist at the NMDA receptor, blocking glutamate signaling in the central nervous system. - Intranasal ketamine · Rhode Island Hospital · Psychiatry / Pain Management
Intranasal ketamine is a rapid-acting NMDA receptor antagonist that blocks glutamate signaling in the brain to produce fast-onset antidepressant and analgesic effects. - Intra-nasal ketamine · Lions Gate Hospital · Psychiatry, Pain Management, Anesthesia
Intranasal ketamine is a non-competitive NMDA receptor antagonist that rapidly blocks glutamate signaling in the brain to produce dissociative and analgesic effects. - Ketamine Injectable Product · Hackensack Meridian Health · Anesthesia, Pain Management, Psychiatry
Ketamine is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor that blocks glutamate signaling in the central nervous system. - Intraoperative infusion of esketamine · Nanjing First Hospital, Nanjing Medical University · Anesthesia
Esketamine is an NMDA receptor antagonist that blocks glutamate signaling in the central nervous system, providing rapid-onset anesthesia and analgesia during surgical procedures. - Memantine Hydrochloride Tablets · University of Virginia · Neurology
Memantine is an uncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor that reduces excessive glutamate-mediated neuronal excitotoxicity. - Memantine (Namenda®) · Washington University School of Medicine · Neurology
Memantine is an uncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor that blocks excessive glutamate signaling in the brain. - Memantine (once daily) · H. Lundbeck A/S · Neurology
Memantine is an uncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor that reduces excessive glutamate-mediated neuronal excitotoxicity.
Phase 3 pipeline (13)
- IM Ketamine · Tel-Aviv Sourasky Medical Center · Psychiatry / Pain Management
IM Ketamine is an N-methyl-D-aspartate (NMDA) receptor antagonist administered intramuscularly that produces rapid-onset dissociative anesthesia and analgesia. - Memantine-XR · University of North Carolina, Chapel Hill · Neurology
Memantine-XR is an extended-release formulation of memantine, an uncompetitive NMDA receptor antagonist that blocks excessive glutamate signaling in the brain. - Continuous ketamine infusion · NYU Langone Health · Psychiatry / Mental Health
Ketamine blocks NMDA glutamate receptors in the brain, rapidly reducing depressive symptoms through dissociative and neuromodulatory effects. - nefopam, ketoprofen, paracetamol · American University of Beirut Medical Center · Pain management
Nefopam is a non-opioid analgesic that acts as an NMDA receptor antagonist, inhibiting the release of pain-producing neurotransmitters. - Namenda/Memantine · State University of New York - Upstate Medical University · Neurology
Memantine is an uncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor that blocks excessive glutamate signaling in the brain. - CI-581b · New York State Psychiatric Institute · Psychiatry
CI-581b is a dissociative anesthetic that acts as an NMDA receptor antagonist to produce rapid-onset antidepressant effects. - Fasedienol Nasal Spray · VistaGen Therapeutics, Inc. · Psychiatry / Neurology
Fasedienol is a NMDA receptor antagonist administered as a nasal spray for rapid-onset treatment of depression. - Esketamine Nasal Product · Dr. Inge Winter · Psychiatry / Neurology
Esketamine is an NMDA receptor antagonist that rapidly blocks glutamate signaling in the brain to produce fast-acting antidepressant effects. - CI-581a · New York State Psychiatric Institute · Anesthesia
CI-581a is a dissociative anesthetic that acts as an NMDA receptor antagonist to produce rapid-onset anesthesia and analgesia. - IN ketamine · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Psychiatry / Pain Management
Intranasal ketamine is a rapid-acting NMDA receptor antagonist that blocks glutamate signaling in the brain to produce fast-onset antidepressant and analgesic effects. - IV Ketamine · Icahn School of Medicine at Mount Sinai · Psychiatry / Pain Management
IV ketamine is an NMDA receptor antagonist that blocks glutamate signaling in the brain, producing rapid-onset dissociative and analgesic effects. - AM-101 · Auris Medical AG · Otolaryngology / Neurology
AM-101 is an intratympanic injection that delivers a small-molecule NMDA receptor antagonist to the inner ear to reduce tinnitus perception. - Memantine (Ebixa) · University of Lisbon · Neurology
Memantine is an uncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor that blocks excessive glutamate signaling in the brain.
Phase 2 pipeline (4)
- AZD6765 iv · AstraZeneca · Psychiatry
AZD6765 is an NMDA receptor antagonist that modulates glutamatergic neurotransmission to produce rapid-acting antidepressant effects. - Esketamine DPI - low dose · Celon Pharma SA · Psychiatry / Neurology
Esketamine is an NMDA receptor antagonist that blocks glutamate signaling in the brain, with rapid-acting antidepressant effects. - Augment with Memantine · Shanghai Mental Health Center · Neurology
Augment with Memantine is a combination of a glutamate receptor antagonist and a NMDA receptor antagonist, which may help to improve cognitive function in patients with Alzheimer's disease. - APD403 IV · Acacia Pharma Ltd · Anesthesiology
APD403 IV is an anesthetic agent that works by blocking N-methyl-D-aspartate (NMDA) receptors.