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Procedural sedation with ketamine alone
Ketamine is a non-competitive NMDA receptor antagonist that produces rapid-onset dissociative sedation and analgesia suitable for procedural use.
Ketamine is a non-competitive NMDA receptor antagonist that produces rapid-onset dissociative sedation and analgesia suitable for procedural use. Used for Procedural sedation and analgesia for diagnostic and therapeutic procedures.
At a glance
| Generic name | Procedural sedation with ketamine alone |
|---|---|
| Sponsor | Centre Hospitalier Universitaire de Nice |
| Drug class | NMDA receptor antagonist |
| Target | NMDA receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Procedural Sedation |
| Phase | FDA-approved |
Mechanism of action
Ketamine blocks N-methyl-D-aspartate (NMDA) glutamate receptors in the central nervous system, producing dissociative anesthesia characterized by sedation, analgesia, and preserved airway reflexes. This mechanism allows patients to remain responsive while achieving adequate sedation for painful procedures, with the added benefit of analgesia that reduces the need for opioids.
Approved indications
- Procedural sedation and analgesia for diagnostic and therapeutic procedures
Common side effects
- Dissociation/emergence reactions
- Increased heart rate and blood pressure
- Nausea and vomiting
- Dizziness
- Transient visual disturbances
Key clinical trials
- Intranasal Dexmedetomidine Plus Ketamine for Procedural Sedation (PHASE2, PHASE3)
- A Study to Evaluate Efficacy and Safety of MELT-300 for Procedural Sedation in Subjects Undergoing Cataract Extraction With Lens Replacement (CELR) (PHASE3)
- Inhalation of Sevoflurane Versus Intravenous Midazolam,Ketamine,Propofol For Pediatrics Undergoing Upper GI Endoscopy (NA)
- Efficacy of Magnetic Resonance-guided High Intensity Focused Ultrasound for the Ablation of Breast Cancer (NA)
- Dexmedetomidine Versus Midazolam Added to Ketamine in Pediatric Patients Undergoing Bone Marrow Aspiration and Biopsy (NA)
- Evaluation of a New Protocol for Adult Procedural Sedation With Ketamine-propofol in a 1 on 4 Ratio
- Intranasal Versus Intravenous Ketamine for Procedural Sedation in Children (PHASE3)
- Ketamine Versus Co-administration of Ketamine and Propofol for Procedural Sedation in a Pediatric Emergency Department (PHASE3)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |