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Intraoperative infusion of esketamine
Esketamine is an NMDA receptor antagonist that blocks glutamate signaling in the central nervous system, providing rapid-onset anesthesia and analgesia during surgical procedures.
Esketamine is an NMDA receptor antagonist that blocks glutamate signaling in the central nervous system, providing rapid-onset anesthesia and analgesia during surgical procedures. Used for Intraoperative anesthesia and analgesia during surgical procedures.
At a glance
| Generic name | Intraoperative infusion of esketamine |
|---|---|
| Sponsor | Nanjing First Hospital, Nanjing Medical University |
| Drug class | NMDA receptor antagonist |
| Target | NMDA receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Esketamine, the S-enantiomer of ketamine, acts as a non-competitive antagonist at the N-methyl-D-aspartate (NMDA) receptor, which is an ionotropic glutamate receptor. When administered intraoperatively, it produces dissociative anesthesia characterized by analgesia, sedation, and amnesia while maintaining airway reflexes and respiratory drive. The drug's rapid onset and offset make it suitable for perioperative use.
Approved indications
- Intraoperative anesthesia and analgesia during surgical procedures
Common side effects
- Dissociation
- Increased heart rate
- Increased blood pressure
- Emergence reactions
- Dizziness
Key clinical trials
- Esketamine for Prevention of Depression After Cytoreductive Surgery in Ovarian Cancer (NA)
- Effect of Continuous Intraoperative Esketamine Infusion on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Mild-to-Severe Depression (NA)
- Effect of Esketamine on Perioperative Negative Emotions in Patients Undergoing Breast Cancer Surgery (NA)
- Intraoperative Multimodal Monitoring as a Means in Reducing the Duration of Mechanical Ventilation in High-Risk Patients Undergoing Major Abdominal Procedures - A Pilot Study (NA)
- Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy (NA)
- Effect of Opioid-free Anaesthesia on Postoperative Delirium in Elderly Patients Undergoing Gastrointestinal Surgery (PHASE4)
- Clinical Study of Perioperative Sleep Disorders in Cardiac Surgery (PHASE4)
- Esketamine and Butorphanol for Post-Lobectomy Pain (PHASE4)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |