{"id":"intraoperative-infusion-of-esketamine","safety":{"commonSideEffects":[{"rate":null,"effect":"Dissociation"},{"rate":null,"effect":"Increased heart rate"},{"rate":null,"effect":"Increased blood pressure"},{"rate":null,"effect":"Emergence reactions"},{"rate":null,"effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL2364609","moleculeType":"Small molecule","molecularWeight":"274.19"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Esketamine, the S-enantiomer of ketamine, acts as a non-competitive antagonist at the N-methyl-D-aspartate (NMDA) receptor, which is an ionotropic glutamate receptor. When administered intraoperatively, it produces dissociative anesthesia characterized by analgesia, sedation, and amnesia while maintaining airway reflexes and respiratory drive. The drug's rapid onset and offset make it suitable for perioperative use.","oneSentence":"Esketamine is an NMDA receptor antagonist that blocks glutamate signaling in the central nervous system, providing rapid-onset anesthesia and analgesia during surgical procedures.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:40:55.091Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Intraoperative anesthesia and analgesia during surgical procedures"}]},"trialDetails":[{"nctId":"NCT06624878","phase":"NA","title":"Esketamine for Prevention of Depression After Cytoreductive Surgery in Ovarian Cancer","status":"COMPLETED","sponsor":"Zhejiang Cancer Hospital","startDate":"2024-10-08","conditions":"Ovarian Cancer, Cytoreductive Surgery, Depressive Symptom","enrollment":568},{"nctId":"NCT07374198","phase":"NA","title":"Effect of Continuous Intraoperative Esketamine Infusion on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Mild-to-Severe Depression","status":"NOT_YET_RECRUITING","sponsor":"Chinese PLA General Hospital","startDate":"2026-01-18","conditions":"Depression, Anxiety, S-ketamine","enrollment":142},{"nctId":"NCT07367542","phase":"NA","title":"Effect of Esketamine on Perioperative Negative Emotions in Patients Undergoing Breast Cancer Surgery","status":"NOT_YET_RECRUITING","sponsor":"Chinese PLA General Hospital","startDate":"2026-01-17","conditions":"Depression, Anxiety, S-ketamine","enrollment":218},{"nctId":"NCT07339449","phase":"NA","title":"Intraoperative Multimodal Monitoring as a Means in Reducing the Duration of Mechanical Ventilation in High-Risk Patients Undergoing Major Abdominal Procedures - A Pilot Study","status":"RECRUITING","sponsor":"University Hospital Dubrava","startDate":"2025-08-01","conditions":"Major Abdominal Surgeries, Mechanical Ventilation","enrollment":100},{"nctId":"NCT07084753","phase":"NA","title":"Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy","status":"NOT_YET_RECRUITING","sponsor":"IVO JURISIC","startDate":"2025-07-30","conditions":"Obese Patients, Bariatric Surgical Pain, Bariatric Surgery (Sleeve Gastrectomy )","enrollment":36},{"nctId":"NCT06958393","phase":"PHASE4","title":"Effect of Opioid-free Anaesthesia on Postoperative Delirium in Elderly Patients Undergoing Gastrointestinal Surgery","status":"NOT_YET_RECRUITING","sponsor":"Qianfoshan Hospital","startDate":"2025-05-20","conditions":"Delirium - Postoperative, Opioid-Free Anaesthesia","enrollment":406},{"nctId":"NCT06778811","phase":"PHASE4","title":"Clinical Study of Perioperative Sleep Disorders in Cardiac Surgery","status":"RECRUITING","sponsor":"Nanjing First Hospital, Nanjing Medical University","startDate":"2024-10-11","conditions":"Sleep Wake Disorders, Esketamine and the Quality of Recovery, Dexmedetomidine","enrollment":180},{"nctId":"NCT06398834","phase":"PHASE4","title":"Esketamine and Butorphanol for Post-Lobectomy Pain","status":"COMPLETED","sponsor":"Second People's Hospital of Hefei City","startDate":"2022-03-01","conditions":"Esketamine, Pain, Post-thoracotomy Pain Syndrome","enrollment":223},{"nctId":"NCT06199011","phase":"NA","title":"Effect of Esketamine on Depressive Symptoms of Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy","status":"UNKNOWN","sponsor":"The Second Hospital of Anhui Medical University","startDate":"2024-01-01","conditions":"Depressive Symptoms","enrollment":400},{"nctId":"NCT05506787","phase":"PHASE4","title":"The Effects of Intraoperative Esketamine on Postoperative Pain and Mood in Patients With Inflammatory Bowel Disease","status":"COMPLETED","sponsor":"Jinling Hospital, China","startDate":"2020-09-01","conditions":"Crohn Disease, Depression, Esketamine","enrollment":120},{"nctId":"NCT05289050","phase":"PHASE4","title":"Analgesic Effect of Intraoperative Intravenous S-Ketamine During Total Knee Arthroplasty Surgery","status":"UNKNOWN","sponsor":"Ling Dong","startDate":"2022-04-19","conditions":"Postoperative Pain, Acute, Anaesthetic","enrollment":144},{"nctId":"NCT05016128","phase":"NA","title":"Intraoperative S-ketamine to Prevent Postoperative Hyperalgesia in Patients Undergoing Video-assisted Thoracic Surgery","status":"UNKNOWN","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2021-08-17","conditions":"Postoperative Hyperalgesia","enrollment":92},{"nctId":"NCT04682782","phase":"PHASE4","title":"Intraoperative Small-dose Esketamine Infusion for Pain Control in Burn Patients","status":"UNKNOWN","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2020-07-14","conditions":"Burns","enrollment":26},{"nctId":"NCT02085577","phase":"PHASE4","title":"The Effect of Intraoperative Ketamine on Opioid Consumption and Pain After Spine Surgery in Opioid-dependent Patients","status":"COMPLETED","sponsor":"Rigshospitalet, Denmark","startDate":"2014-05","conditions":"Postoperative Pain, Chronic Pain, Analgesics","enrollment":147},{"nctId":"NCT02421913","phase":"PHASE4","title":"Efficacy of S(+)-Ketamine Administered as a Continuous Infusion for the Control of Postoperative Pain","status":"COMPLETED","sponsor":"Centro Medico Campinas","startDate":"2012-06","conditions":"Postoperative Pain","enrollment":42}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":55,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Intraoperative infusion of esketamine","genericName":"Intraoperative infusion of esketamine","companyName":"Nanjing First Hospital, Nanjing Medical University","companyId":"nanjing-first-hospital-nanjing-medical-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Esketamine is an NMDA receptor antagonist that blocks glutamate signaling in the central nervous system, providing rapid-onset anesthesia and analgesia during surgical procedures. Used for Intraoperative anesthesia and analgesia during surgical procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}