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ketamine sedation versus midazolam sedation
Ketamine acts as an NMDA receptor antagonist, blocking the action of glutamate in the brain.
Ketamine acts as an NMDA receptor antagonist, blocking the action of glutamate in the brain. Used for Sedation for diagnostic or surgical procedures.
At a glance
| Generic name | ketamine sedation versus midazolam sedation |
|---|---|
| Also known as | ketamine sedation |
| Sponsor | Universidad de Colima |
| Drug class | Anesthetic |
| Target | NMDA receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | Phase 3 |
Mechanism of action
This leads to a dissociative effect, reducing consciousness and pain perception. Ketamine's mechanism is complex and not fully understood, but it is thought to involve multiple receptor subtypes and downstream signaling pathways.
Approved indications
- Sedation for diagnostic or surgical procedures
Common side effects
- Hallucinations
- Dizziness
- Nausea
- Vomiting
Key clinical trials
- Comparison Between Two Drugs in Sedation of Upper GI Endoscopy
- Adjuvant Continuous Infusion of Nefopam Versus Standard of Care in Mechanically Ventilated Critically Ill Patients: Randomized Double-blind Controlled Study (PHASE3)
- Dexmedetomidine Versus Ketamine-midazolam Sedation in Awake Fiberoptic Intubation in Suspected Difficult Airway (PHASE4)
- Sedation Versus Protective Stabilization for Pediatric Dental Treatment (PHASE4)
- Propofol or Benzodiazepine Combined With Ketamine for Procedural Sedation in Emergency Setting (EARLY_PHASE1)
- Dexmedetomidine-ketamine Combination Versus Fentanyl-midazolam During Bronchoscopy (PHASE3)
- Remifentanil Plus Ketamine for Dynamic Flexible Bronchoscopy (PHASE4)
- Esketamine Induction Intubation in ICU Patients. (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
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