Dexmedetomidine-ketamine Combination Versus Fentanyl-midazolam During Bronchoscopy

NCT06185127 PHASE3 COMPLETED

Sedation during flexible bronchoscopy (FB) should maintain an adequate respiratory drive, ensure maximum comfort for the patient, and warrant that the objectives of the procedure are achieved. Nevertheless, the optimal sedation method for FB has yet to be established. This study aimed to compare the standard recommended combination of midazolam-fentanyl (MF) with that of dexmedetomidine-ketamine (DK) for patient sedation during FB. Patients subjected to FB were randomly assigned to a DK (n=25) and an MF group (n=25). The primary outcome was the rate of critical desaturation events (arterial oxygen saturation \<80% with nasal oxygen supply 2 L/min). Secondary outcomes included sedation depth, hemodynamic complications, adverse events, and patient and bronchoscopist satisfaction.

Details

Lead sponsor	University of Patras
Phase	PHASE3
Status	COMPLETED
Enrolment	50
Start date	Sun Sep 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Mon Aug 31 2020 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Lung Diseases
• Diagnosis
• Anesthesia

Interventions

• Dexmedetomidine
• Ketamine
• Midazolam
• Fentanyl

Countries

Greece