Last reviewed 2026-04-20 · How we verify

Ketamine perfusion

Ketamine perfusion, developed by the University of Tunis El Manar, is an intravenous formulation of ketamine used primarily for anesthesia and pain management. It has shown promise in treating conditions such as chronic pain and depression, though it lacks an FDA label. The drug's rapid onset and short duration of action make it suitable for various clinical settings. However, its use is associated with several side effects, including dissociation and hallucinations, which require careful monitoring. Despite these challenges, ketamine perfusion remains a valuable tool in the anesthesiologist's arsenal.

At a glance

Approved indications

No approved indications tracked.

Pipeline indications

Common side effects

No common side effects on file.

Drug interactions

• MAOIs
• Other CNS depressants

Key clinical trials

• Ketamine-lidocaine Versus Ketamine-fentanyl for Induction of Anesthesia in Patients With Left Ventricular Systolic Dysfunction Undergoing Elective Coronary Artery Bypass (NA)
• Evaluation of the Initial Prescription of Ketamine and Milnacipran in Depression in Patients With a Progressive Disease (PHASE2, PHASE3)
• Effects of Ketamine in the Acute Phase of Suicidal Ideation (PHASE3)
• Superficial Cervical Plexus Block Versus Ketamine in the Prevention of Chronic Pain After Thyroidectomy (PHASE4)
• The Postoperative Lidocaine and Ketamine Effects on Morphine Requirement in Bariatric Surgery
• Tolerance Assesment of the Usage of an Analgesic Dose of Esketamine for Treatment of Moderate to Intense Pain in an Emergency Departement
• Comparison of Ketamine and Esketamine in Patients Suffering From Fibromyalgia Syndrome. (NA)
• Role of Low Dose Epinephrine Boluses In Acute Hypotension (NA)

Primary sources

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