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combination of Ketamine and Propofol
combination of Ketamine and Propofol is a Anesthetic Small molecule drug developed by Nantes University Hospital. It is currently in Phase 3 development for General anesthesia for surgical procedures.
Ketamine and Propofol work together to induce general anesthesia by modulating NMDA receptors and inhibiting GABA uptake.
Ketamine and Propofol work together to induce general anesthesia by modulating NMDA receptors and inhibiting GABA uptake. Used for General anesthesia for surgical procedures.
At a glance
| Generic name | combination of Ketamine and Propofol |
|---|---|
| Sponsor | Nantes University Hospital |
| Drug class | Anesthetic |
| Target | NMDA receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | Phase 3 |
Mechanism of action
Ketamine acts as an NMDA receptor antagonist, while Propofol inhibits GABA reuptake, leading to a synergistic effect that induces sedation and amnesia. This combination allows for a rapid onset of action and a short duration of anesthesia.
Approved indications
- General anesthesia for surgical procedures
Common side effects
- Respiratory depression
- Hypotension
- Emergence delirium
Key clinical trials
- Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery. (NA)
- Treatment Response In ECT Patients
- Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery (NA)
- Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS) (NA)
- Effects of Different Sedation Techniques on Early Cognitive Recovery After Ambulatory Gynecologic Surgery (NA)
- Night-time Dexmedetomidine-esketamine Infusion and Sleep Quality in ICU Patients (PHASE4)
- Best Hypnotic Drug Choice for Rapid Sequence Induction in the Operating Room (PHASE3)
- Intravenous Sedation and Analgesia Versus Local Anesthesia During Microwave Ablation of Benign Thyroid Nodules (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- combination of Ketamine and Propofol CI brief — competitive landscape report
- combination of Ketamine and Propofol updates RSS · CI watch RSS
- Nantes University Hospital portfolio CI
Frequently asked questions about combination of Ketamine and Propofol
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Related
- Drug class: All Anesthetic drugs
- Target: All drugs targeting NMDA receptor
- Manufacturer: Nantes University Hospital — full pipeline
- Therapeutic area: All drugs in Anesthesiology
- Indication: Drugs for General anesthesia for surgical procedures
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