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Magnesium Sulfate high dose
High-dose magnesium sulfate acts as a NMDA receptor antagonist and stabilizes neuronal membranes, reducing excitotoxicity and seizure activity.
High-dose magnesium sulfate acts as a NMDA receptor antagonist and stabilizes neuronal membranes, reducing excitotoxicity and seizure activity. Used for Seizure prophylaxis in preeclampsia/eclampsia, Acute seizure management, Neuroprotection in acute neurological injury.
At a glance
| Generic name | Magnesium Sulfate high dose |
|---|---|
| Also known as | Magnesium Sulfate |
| Sponsor | Dr Olu Bamgbade, MD, FRCPC |
| Drug class | NMDA receptor antagonist / Anticonvulsant |
| Target | NMDA receptor |
| Modality | Small molecule |
| Therapeutic area | Neurology |
| Phase | Phase 3 |
Mechanism of action
Magnesium sulfate blocks NMDA (N-methyl-D-aspartate) glutamate receptors in a voltage-dependent manner, reducing excessive neuronal excitation. It also stabilizes cell membranes and modulates calcium influx, which contributes to neuroprotection. At high doses, these mechanisms are leveraged to prevent or treat seizures and reduce neurological injury in acute settings.
Approved indications
- Seizure prophylaxis in preeclampsia/eclampsia
- Acute seizure management
- Neuroprotection in acute neurological injury
Common side effects
- Flushing
- Hypotension
- Hypermagnesemia
- Muscle weakness
- Respiratory depression
- Loss of deep tendon reflexes
Key clinical trials
- Adding Magnesium Sulphate to Combined Pectointercostal Plane and Erector Spinae Plane Blocks for Acute and Chronic Post-Mastectomy Pain (NA)
- Adding Magnesium Sulfate to Combined Pecto-Intercostal & Serratus Anterior Planes Block on Post-operative Analgesia in Patients Undergoing Modified Radical Mastectomy (NA)
- Ketamine Versus Magnesium Sulphate as Adjuvants for ESPB in Breast Cancer Surgery (PHASE2)
- Rate, Rhythm or Risk Control for New-onset Supraventricular Arrhythmia During Septic Shock: a Randomized Controlled Trial (NA)
- Diuretic Treatment in Acute Heart Failure With Volume Overload Guided by Serial Spot Urine Sodium Assessment (PHASE4)
- Magnesium Supplementation in Simultaneous Pancreas-Kidney Transplantation
- ESKETamine for FIBromyalgia Treatment (NA)
- Two Doses of the Intravenous Magnesium Sulfate Versus the Standard Single Dose ,With/ Without the Nebulized Budesonide For the Management of the Severe Asthma Exacerbation in the Emergency Room; A Randomized Controlled Trial. (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Magnesium Sulfate high dose CI brief — competitive landscape report
- Magnesium Sulfate high dose updates RSS · CI watch RSS
- Dr Olu Bamgbade, MD, FRCPC portfolio CI