{"id":"magnesium-sulfate-high-dose","safety":{"commonSideEffects":[{"rate":null,"effect":"Flushing"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Hypermagnesemia"},{"rate":null,"effect":"Muscle weakness"},{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Loss of deep tendon reflexes"}]},"_chembl":null,"_fixedAt":"2026-03-30T17:12:53.023144","_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Magnesium sulfate blocks NMDA (N-methyl-D-aspartate) glutamate receptors in a voltage-dependent manner, reducing excessive neuronal excitation. It also stabilizes cell membranes and modulates calcium influx, which contributes to neuroprotection. At high doses, these mechanisms are leveraged to prevent or treat seizures and reduce neurological injury in acute settings.","oneSentence":"High-dose magnesium sulfate acts as a NMDA receptor antagonist and stabilizes neuronal membranes, reducing excitotoxicity and seizure activity.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:20:03.164Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Seizure prophylaxis in preeclampsia/eclampsia"},{"name":"Acute seizure management"},{"name":"Neuroprotection in acute neurological injury"}]},"_fixedFields":["pubmed(121)"],"trialDetails":[{"nctId":"NCT07438366","phase":"NA","title":"Adding Magnesium Sulphate to Combined Pectointercostal Plane and Erector Spinae Plane Blocks for Acute and Chronic Post-Mastectomy Pain","status":"NOT_YET_RECRUITING","sponsor":"South Egypt Cancer Institute","startDate":"2026-02-15","conditions":"Post-mastectomy Pain 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the Standard Single Dose ,With/ Without the Nebulized Budesonide For the Management of the Severe Asthma Exacerbation in the Emergency Room; A Randomized Controlled Trial.","status":"UNKNOWN","sponsor":"Hamad Medical Corporation","startDate":"2015-06","conditions":"Bronchial Asthma","enrollment":240},{"nctId":"NCT04599868","phase":"PHASE2","title":"High Versus Low Dose of Magnesium Sulfate as Initial Tocolytic Agent for Preterm Labour in Symptomatic Placenta Previa.","status":"COMPLETED","sponsor":"Assiut University","startDate":"2020-12-01","conditions":"Placenta Previa Bleeding","enrollment":130},{"nctId":"NCT04223219","phase":"PHASE4","title":"Different Modalities of Analgesia in Open Heart Surgeries in Mansoura University","status":"UNKNOWN","sponsor":"Mansoura University","startDate":"2019-12-10","conditions":"Coronary Artery Disease, Valve Disease, Heart, Pain, Acute","enrollment":90},{"nctId":"NCT04544163","phase":"NA","title":"Magnesium Versus High Dose Fentanyl in Endotracheal 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of Intensive Care Mangement on Maternal and Fetal Outcome of Severe Preeclampsia and Eclampsia","status":"COMPLETED","sponsor":"Cairo University","startDate":"2015-10-01","conditions":"Hypertensive Disorder of Pregnancy","enrollment":1238}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":121,"recentPublications":[{"date":"2026 Jan 31","pmid":"41537746","title":"Magnesium Sulfate Alleviates Sepsis-Associated Acute Kidney Injury by Reducing Inflammation, Oxidative Stress, and Apoptosis via Inhibiting the NF-κB Pathway.","journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology"},{"date":"2025 Sep 26","pmid":"41005958","title":"Hypomagnesaemia with secondary hypocalcaemia due to a novel TRPM6 mutation.","journal":"BMJ case reports"},{"date":"2025 Dec 20","pmid":"40900842","title":"Preventive and therapeutic effects of magnesium sulfate on nikethamide-induced seizures: Implications for COVID-19 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Used for Seizure prophylaxis in preeclampsia/eclampsia, Acute seizure management, Neuroprotection in acute neurological injury.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}