General Anesthetic

This page covers all General Anesthetic drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Glutamate [NMDA] receptor, GABA-A receptor, GABA-A receptor, NMDA glutamate receptor.

Targets

Glutamate [NMDA] receptor · GABA-A receptor · GABA-A receptor, NMDA glutamate receptor · Glycine receptor subunit alpha-1 · GABA A receptors · GABA-A receptor, glutamate receptors · NMDA receptor · GABA_A receptor

Marketed (9)

• Ketalar · Ph Health · Metabolic
  Ketamine works by blocking the action of glutamate at the NMDA receptor, which is involved in pain perception and memory formation.
• Saline + Propofol · Seoul National University Hospital · Anesthesiology
  Propofol dissolved in saline acts as an intravenous anesthetic by enhancing GABAergic inhibitory neurotransmission in the central nervous system.
• Sevoflurane or Propofol · University Health Network, Toronto · Anesthesiology
  Sevoflurane and Propofol are general anesthetics that enhance inhibitory GABAergic neurotransmission and suppress excitatory glutamatergic signaling in the central nervous system to produce unconsciousness.
• General anesthesia · Universidade Estadual Paulista Júlio de Mesquita Filho · Anesthesiology
  General anesthesia depresses the central nervous system to produce unconsciousness, analgesia, and muscle relaxation for surgical procedures.
• Efrane · Baxter · Metabolic
• Diprivan · Fresenius Kabi · Neuroscience
  Propofol produces sedative/anesthetic effects by positive modulation of inhibitory GABA function through GABA A receptors.
• Propofol MCT · Chung-Ang University Gwangmyeong Hospital · Anesthesia
  Propofol MCT is a medium-chain triglyceride formulation of propofol that acts as a positive allosteric modulator of GABA-A receptors to produce rapid sedation and anesthesia.
• propofol, sevoflurane · Gangnam Severance Hospital · Anesthesiology
  Propofol and sevoflurane are general anesthetics that enhance inhibitory GABA signaling and suppress excitatory glutamate signaling in the central nervous system to induce unconsciousness.
• General anesthetic · Xinhua Hospital, Shanghai Jiao Tong University School of Medicine · Anesthesiology
  General anesthetics depress the central nervous system to produce unconsciousness, analgesia, and muscle relaxation for surgical procedures.

Phase 3 pipeline (1)

• Xenon vs propofol · Rigshospitalet, Denmark · Anesthesiology
  Xenon is a general anesthetic that works by modulating the activity of N-methyl-D-aspartate (NMDA) receptors in the brain.

Phase 2 pipeline (1)

• Intraoperative anesthetic strategy by Desflurane · Assistance Publique - Hôpitaux de Paris · Anesthesiology
  GABA receptor antagonist