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Propofol MCT
Propofol MCT is a medium-chain triglyceride formulation of propofol that acts as a positive allosteric modulator of GABA-A receptors to produce rapid sedation and anesthesia.
Propofol MCT is a medium-chain triglyceride formulation of propofol that acts as a positive allosteric modulator of GABA-A receptors to produce rapid sedation and anesthesia. Used for Induction and maintenance of general anesthesia, Sedation in intensive care units.
At a glance
| Generic name | Propofol MCT |
|---|---|
| Sponsor | Chung-Ang University Gwangmyeong Hospital |
| Drug class | General anesthetic |
| Target | GABA-A receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Propofol enhances inhibitory GABAergic neurotransmission in the central nervous system, leading to sedation, hypnosis, and anesthesia. The MCT (medium-chain triglyceride) formulation improves the pharmacokinetic profile and reduces pain on injection compared to the standard lipid emulsion formulation. This formulation allows for more rapid onset and offset of anesthetic effects.
Approved indications
- Induction and maintenance of general anesthesia
- Sedation in intensive care units
Common side effects
- Hypotension
- Respiratory depression
- Pain on injection
- Bradycardia
- Apnea
Key clinical trials
- Total Intravenous and Balanced Anesthesia in Diabetic Patients Undergoing Video-Assisted Thoracoscopy (PHASE4)
- The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index
- EEG and Pain Monitor Data Under Anesthesia to Study Pharmacodynamic Effects of Opioids and Sedatives (NA)
- Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery (PHASE1)
- Effect of Remimazolam and Propofol on Postoperative Delirium (NA)
- Hemodynamic Effects of Remimazolam vs Propofol During Robot-assisted Gynecologic Surgery (NA)
- Propofol Versus Sevoflurane Anesthesia on the Intraocular Pressure and Hemodynamics in Patient Undergoing Cyclophotocoagulation (NA)
- Actualities in Procedural Sedation: Remimazolam (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Propofol MCT CI brief — competitive landscape report
- Propofol MCT updates RSS · CI watch RSS
- Chung-Ang University Gwangmyeong Hospital portfolio CI