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Sevoflurane or Propofol
Sevoflurane and Propofol are general anesthetics that enhance inhibitory GABAergic neurotransmission and suppress excitatory glutamatergic signaling in the central nervous system to produce unconsciousness.
Sevoflurane and Propofol are general anesthetics that enhance inhibitory GABAergic neurotransmission and suppress excitatory glutamatergic signaling in the central nervous system to produce unconsciousness. Used for Induction and maintenance of general anesthesia for surgical procedures, Sedation in intensive care units.
At a glance
| Generic name | Sevoflurane or Propofol |
|---|---|
| Sponsor | University Health Network, Toronto |
| Drug class | General anesthetic |
| Target | GABA-A receptor, NMDA glutamate receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Sevoflurane is a volatile halogenated ether that potentiates GABA-A receptor function and inhibits NMDA glutamate receptors, leading to rapid anesthetic induction and maintenance. Propofol is an intravenous phenolic compound that similarly enhances GABA-A receptor-mediated chloride influx while inhibiting excitatory neurotransmission, producing sedation and anesthesia with rapid onset and offset.
Approved indications
- Induction and maintenance of general anesthesia for surgical procedures
- Sedation in intensive care units
Common side effects
- Hypotension
- Respiratory depression
- Bradycardia
- Nausea and vomiting (postoperative)
- Emergence delirium (sevoflurane)
- Propofol infusion syndrome (with prolonged high-dose propofol)
Key clinical trials
- The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index
- Prospective Randomized Observer Blinded Single Center Study Comparing 90-day Functional Outcome in Patients Who Received Intravenous Propofol Infusion Versus Inhalational Sevoflurane for General Anesthesia During Mechanical Thrombectomy in Patients Who Suffered From Acute Ischemic Stroke (NA)
- Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy (NA)
- Transition From Acute to Chronic Opioid Use and Chronic Pain (EARLY_PHASE1)
- Comparing Inhalation and Total Intravenous Anesthesia Methods
- Continuous Versus 1-min Oscillometric Arterial BP Monitoring (NA)
- The Effects of Three Different Anesthetic Methods on Postoperative Agitation (NA)
- Effects of an Opioid Free/Sparing Care Pathway for Patients Undergoing Obesity Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Sevoflurane or Propofol CI brief — competitive landscape report
- Sevoflurane or Propofol updates RSS · CI watch RSS
- University Health Network, Toronto portfolio CI