DNA — Drug Target

All drugs that target DNA — marketed and clinical-stage. Includes 25 drug classes acting on this target.

Drug classes

Alkylating agent · Platinum-based chemotherapy agent · Platinum-containing alkylating agent · DNA intercalating agent · Alkylating Agent · Bleomycin-type antibiotic chemotherapy agent · Actinomycin [EPC] · Platinum-based alkylating agent · DNA alkylating agent · Chemotherapeutic antibiotic · Platinum-based chemotherapy · Antibiotic alkylating agent

Marketed (24)

• Melphalan (Mel) · Institute of Hematology & Blood Diseases Hospital, China · Alkylating agent · Oncology
  Melphalan is an alkylating agent that cross-links DNA strands, preventing cell division and causing cancer cell death.
• Eloxatin · Yakult Honsha · Platinum-based chemotherapy agent · Oncology
  Oxaliplatin forms platinum-DNA crosslinks that inhibit replication and transcription.
• Paraplatin · MYLAN SEIYAKU Ltd · Platinum-containing alkylating agent · Oncology
  Carboplatin produces predominantly interstrand DNA cross-links in a cell-cycle nonspecific manner.
• Actinomycin-D · Peking Union Medical College Hospital · DNA intercalating agent · Oncology
  Actinomycin-D intercalates into DNA and inhibits RNA polymerase, preventing transcription and leading to cell death.
• IFO · Italian Sarcoma Group · Alkylating Agent · Oncology
  Ifosfamide is an alkylating agent that cross-links DNA, preventing cell replication and inducing apoptosis.
• Pingyangmycin Injection · Second Affiliated Hospital, School of Medicine, Zhejiang University · Bleomycin-type antibiotic chemotherapy agent · Oncology
  Pingyangmycin is a bleomycin-type antibiotic that intercalates into DNA and causes strand breaks, leading to cell death.
• Oxaliplatin (OXAL) · Memorial Sloan Kettering Cancer Center · Platinum-based chemotherapy agent · Oncology
  Oxaliplatin is a platinum-based chemotherapy agent that forms DNA crosslinks to kill rapidly dividing cancer cells.
• Carboplatin or Cisplatin · Second Hospital of Shanxi Medical University · Platinum-based chemotherapy agent · Oncology
  Carboplatin and cisplatin are platinum-based chemotherapy agents that bind to DNA and form cross-links, preventing DNA replication and triggering cancer cell death.
• Treosulfan (Treo) · Federal Research Institute of Pediatric Hematology, Oncology and Immunology · Alkylating agent · Oncology
  Treosulfan is an alkylating agent that cross-links DNA, causing cell death and used primarily as a myeloablative conditioning agent before hematopoietic stem cell transplantation.
• Melphalan Injection · Hospital das Clínicas de Ribeirão Preto · Alkylating agent · Oncology
  Melphalan is an alkylating agent that cross-links DNA strands, preventing cell division and causing cancer cell death.
• cyclo phosphamide · Al-Azhar University · Alkylating agent · Oncology, Immunology
  Cyclophosphamide is an alkylating agent that cross-links DNA strands, preventing cell division and causing cancer cell death.
• Cyclophosphamide (CYC) · Hansa Biopharma AB · Alkylating agent · Oncology, Immunology
  Cyclophosphamide is an alkylating agent that cross-links DNA strands, preventing cell division and causing cell death in rapidly dividing cells.
• Standard of Care: Cyclophosphamide · H. Lee Moffitt Cancer Center and Research Institute · Alkylating agent · Oncology
  Cyclophosphamide is an alkylating agent that cross-links DNA strands, preventing cell division and causing cancer cell death.
• Cosmegen · Recordati · Actinomycin [EPC] · Oncology
  Dactinomycin binds DNA and inhibits RNA synthesis, demonstrating cytotoxic activity in cancer models.
• Cyclophosphamide (C) · Second Affiliated Hospital, School of Medicine, Zhejiang University · Alkylating agent · Oncology, Immunology
  Cyclophosphamide is an alkylating agent that cross-links DNA, preventing cell division and triggering apoptosis in rapidly dividing cells.
• Carboplatin Injection · Chia Tai Tianqing Pharmaceutical Group Co., Ltd. · Platinum-based chemotherapy agent · Oncology
  Carboplatin is a platinum-based chemotherapy agent that forms DNA crosslinks, preventing cancer cell replication and inducing apoptosis.
• Platinum-Based Chemotherapy · Genprex, Inc. · Platinum-based alkylating agent · Oncology
  Platinum-based chemotherapy drugs form covalent crosslinks with DNA, preventing replication and transcription, thereby inducing cancer cell death.
• cis-platinum · Peking University Third Hospital · Platinum-based alkylating agent · Oncology
  Cisplatin is a platinum-based chemotherapy agent that forms DNA adducts and cross-links, preventing DNA replication and transcription to induce cancer cell death.
• Mitomycin C · University of Erlangen-Nürnberg Medical School · DNA alkylating agent · Oncology
  Mitomycin C is an antibiotic that alkylates DNA and creates cross-links, preventing DNA replication and causing cell death.
• Mitomycin C 0.02% · Shahid Beheshti University of Medical Sciences · Alkylating agent · Oncology; Ophthalmology
  Mitomycin C is an alkylating agent that cross-links DNA, preventing cell division and inducing apoptosis in rapidly dividing cells.
• Mitomycin-C sponge · University of California, San Diego · Alkylating agent · Oncology; Ophthalmology
  Mitomycin-C is an antibiotic that alkylates DNA, causing cross-linking and cell death, used topically to prevent scar tissue formation after ocular surgery.
• CYC · Italian Sarcoma Group · Alkylating agent · Oncology
  CYC is a cyclophosphamide-based chemotherapy agent that alkylates DNA to inhibit cancer cell proliferation.
• Doxil · Pfizer Inc. · Other
  Doxorubicin binds DNA, inhibits nucleic acid synthesis, and induces mutagenesis and chromosomal aberrations.
• carboplatin periocular injection · Sun Yat-sen University · Platinum-based chemotherapy agent · Oncology
  Carboplatin is a platinum-based chemotherapy agent that forms DNA crosslinks to kill rapidly dividing cancer cells.

Phase 3 pipeline (65)

• Cisplatin injection · Guangzhou Double Bioproducts Co., Ltd · Platinum-based chemotherapy agent · Oncology
  Cisplatin is a platinum-based chemotherapy agent that forms DNA crosslinks, preventing DNA replication and transcription in cancer cells.
• Bleomycin Sulfate (BLM) · M.D. Anderson Cancer Center · Chemotherapeutic antibiotic · Oncology
  Bleomycin is a chemotherapeutic antibiotic that binds to DNA and causes strand breaks, leading to cell death.
• Cisplatin-based induction chemotherapy · Ming-Yuan Chen · Platinum-based alkylating agent · Oncology
  Cisplatin is a platinum-based chemotherapy agent that forms DNA crosslinks, preventing DNA replication and transcription in cancer cells.
• Chemotherapy (Cisplatin) · Insel Gruppe AG, University Hospital Bern · Platinum-based alkylating agent · Oncology
  Cisplatin is a platinum-based chemotherapy agent that forms DNA crosslinks, preventing DNA replication and transcription, thereby inducing cancer cell death.
• Carboplatin for Injection · Jiangsu HengRui Medicine Co., Ltd. · Platinum-based chemotherapy agent · Oncology
  Carboplatin is a platinum-based chemotherapy agent that forms DNA crosslinks, preventing cancer cell replication and inducing apoptosis.
• Cisplatin for injection · Shanghai Guangsheng Biopharmaceutical Co., Ltd · Platinum-based chemotherapy agent · Oncology
  Cisplatin is a platinum-based chemotherapy agent that forms DNA crosslinks, preventing DNA replication and transcription in cancer cells.
• Alternative medications: carboplatin · Universität des Saarlandes · Platinum-based chemotherapy agent · Oncology
  Carboplatin is a platinum-based chemotherapy agent that forms DNA crosslinks to kill rapidly dividing cancer cells.
• Oxaliplatin for injection · Shanghai Junshi Bioscience Co., Ltd. · Platinum-based chemotherapy · Oncology
  Oxaliplatin works by interfering with DNA replication in cancer cells, leading to cell death.
• Cisplatin (DDP) · Sun Yat-sen University · Platinum-based alkylating agent · Oncology
  Cisplatin is a platinum-based chemotherapy agent that forms DNA crosslinks, preventing DNA replication and transcription, thereby inducing cancer cell death.
• XELOX intensive treatment group · Zhejiang Cancer Hospital · Platinum-based chemotherapy · Oncology
  Oxaliplatin works by damaging the DNA of cancer cells, preventing them from reproducing.
• oxaliplatin, folinic acid, fluorouracil · GERCOR - Multidisciplinary Oncology Cooperative Group · Platinum-based chemotherapy · Oncology
  Oxaliplatin works by interfering with DNA replication in cancer cells, causing cell death.
• Oxaliplatin intravenous · Federation Francophone de Cancerologie Digestive · Platinum-based chemotherapy agent · Oncology
  Oxaliplatin is a platinum-based chemotherapy agent that forms DNA crosslinks to inhibit cancer cell replication and induce apoptosis.
• oxaliplatin;s1 · Chinese Academy of Medical Sciences · Platinum-based chemotherapy · Oncology
  Oxaliplatin is a platinum-based chemotherapy drug that works by crosslinking DNA, thereby inhibiting DNA replication and transcription.
• Carboplatin/Paraplatin · Bristol-Myers Squibb · Platinum-based alkylating agent · Oncology
  Carboplatin is a platinum-based chemotherapy agent that forms DNA crosslinks, preventing cancer cell replication and inducing cell death.
• Dicycloplatin (TP21) · Gao-jun Teng · Platinum-based chemotherapy agent · Oncology
  Dicycloplatin is a platinum-based chemotherapy agent that forms DNA crosslinks to inhibit cancer cell proliferation.
• Mitomycin (MM) · University of Sydney · Antibiotic alkylating agent · Oncology
  Mitomycin is an antibiotic that alkylates DNA, causing cross-linking and strand breaks that prevent cell division and induce apoptosis.
• clofarabine (IV formulation) · Genzyme, a Sanofi Company · Nucleoside analog · Oncology
  Clofarabine is a nucleoside analog that interferes with DNA synthesis, leading to cell death in rapidly dividing cancer cells.
• Cisplatin (as radiosensitizer) · Merck Sharp & Dohme LLC · Platinum-based chemotherapy agent · Oncology
  Cisplatin acts as a radiosensitizer by forming DNA adducts that enhance the cytotoxic effects of ionizing radiation, making cancer cells more susceptible to radiation-induced damage.
• cisplatin i.p. · West China Second University Hospital · Platinum-based alkylating agent · Oncology
  Cisplatin is a platinum-based chemotherapy agent that forms DNA crosslinks, preventing DNA replication and transcription in cancer cells.
• Cisplatin/Platinol · Bristol-Myers Squibb · Platinum-based alkylating agent · Oncology
  Cisplatin is a platinum-based chemotherapy agent that forms DNA crosslinks, preventing DNA replication and triggering cancer cell death.
• Dacarbazine (DTIC) · M.D. Anderson Cancer Center · Alkylating agent · Oncology
  Dacarbazine is an alkylating agent that cross-links DNA, preventing cell division and causing cancer cell death.
• Vinflunine plus Capecitabine · Pierre Fabre Medicament · Platinum-based chemotherapeutic agent and fluoropyrimidine · Oncology
  Vinflunine is a chemotherapeutic agent that intercalates DNA, thereby inhibiting DNA replication and transcription, while Capecitabine is a prodrug that is converted into 5-fluorouracil, which inhibits thymidylate synthase.
• Platinum-Based Drug · Chinese Academy of Medical Sciences · Platinum-based chemotherapy agent · Oncology
  Platinum-based drugs form covalent crosslinks with DNA, preventing replication and transcription to induce cancer cell death.
• Cyclophosphamide injections · Astellas Pharma China, Inc. · Alkylating agent · Oncology
  Cyclophosphamide is an alkylating agent that cross-links DNA strands, preventing cell division and triggering apoptosis in rapidly dividing cells.
• concomitant cisplatin · Groupe Oncologie Radiotherapie Tete et Cou · Platinum-based chemotherapy · Oncology
  Cisplatin works by interfering with DNA replication, causing cell death in rapidly dividing cancer cells.
• Cisplatin for Injection / Carboplatin Injection · Shanghai Junshi Bioscience Co., Ltd. · Platinum-based chemotherapy agent · Oncology
  Cisplatin and carboplatin are platinum-based chemotherapy agents that bind to DNA and cause cross-linking, leading to cell death.
• Oxaliplatin(Aiheng) · The First Affiliated Hospital of Henan University of Science and Technology · Platinum-based chemotherapy · Oncology
  Oxaliplatin works by interfering with DNA replication in cancer cells, leading to cell death.
• Oxaliplatin during radiotherapy · Universitätsmedizin Mannheim · Platinum-based chemotherapy agent · Oncology
  Oxaliplatin is a platinum-based chemotherapy agent that forms DNA crosslinks to kill cancer cells, and when combined with radiotherapy, enhances radiation-induced cell death through synergistic DNA damage.
• carboplatin/cisplatin-etoposide · Shanghai Henlius Biotech · platinum-based chemotherapeutic agents · Oncology
  Carboplatin and cisplatin-etoposide work by interfering with DNA replication in cancer cells, ultimately leading to cell death.
• Cisplatin 1 · Sun Yat-sen University · Platinum-based chemotherapy agent · Oncology
  Cisplatin is a platinum-based chemotherapy agent that forms DNA crosslinks, preventing DNA replication and transcription in cancer cells.
• oxaliplatin+Leucovorin+5-FU · Xu jianmin · Platinum-based chemotherapy · Oncology
  Oxaliplatin works by interfering with DNA replication in cancer cells, while 5-FU is a thymidylate synthase inhibitor that disrupts DNA synthesis, and Leucovorin is a folate analog that helps stabilize 5-FU.
• Drug：Cisplatin · Sun Yat-sen University · Platinum-based alkylating agent · Oncology
  Cisplatin is a platinum-based chemotherapy agent that forms DNA crosslinks, preventing DNA replication and transcription, thereby inducing cancer cell death.
• Oxaliplatin Based Chemotherapy · Amgen · Platinum-based chemotherapy agent · Oncology
  Oxaliplatin is a platinum-based chemotherapy agent that forms DNA crosslinks to kill rapidly dividing cancer cells.
• Cisplatin 2 · Sun Yat-sen University · Platinum-based alkylating agent · Oncology
  Cisplatin is a platinum-based chemotherapy agent that forms DNA crosslinks, preventing DNA replication and transcription in cancer cells.
• Cisplatin (arm B) · Taiho Pharmaceutical Co., Ltd. · Platinum-based chemotherapy agent · Oncology
  Cisplatin is a platinum-based chemotherapy agent that forms DNA adducts and crosslinks, preventing DNA replication and triggering cancer cell death.
• Carboplatin (neoadjuvant） · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Platinum-based chemotherapy agent · Oncology
  Carboplatin is a platinum-based chemotherapy agent that forms DNA crosslinks to kill rapidly dividing cancer cells.
• Cisplatin（adjuvant） · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Platinum-based alkylating agent · Oncology
  Cisplatin is a platinum-based chemotherapy agent that forms DNA crosslinks, preventing DNA replication and triggering cancer cell death.
• weekly cisplatin · Korea Cancer Center Hospital · Platinum-based chemotherapy agent · Oncology
  Weekly cisplatin is a platinum-based chemotherapy agent that forms DNA crosslinks to inhibit cancer cell replication and induce apoptosis.
• Carboplatin (adjuvant） · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Platinum-based chemotherapy agent · Oncology
  Carboplatin is a platinum-based chemotherapy agent that forms DNA crosslinks to kill rapidly dividing cancer cells.
• chlorambucil (drug) · International Extranodal Lymphoma Study Group (IELSG) · Alkylating agent · Oncology
  Chlorambucil is an alkylating agent that cross-links DNA strands, preventing cell division and causing cancer cell death.

Phase 2 pipeline (17)

• CDDP 75 · Holy Name Medical Center, Inc. · Platinum-based chemotherapy · Oncology
  CDDP 75 is a platinum-based chemotherapy drug that works by crosslinking DNA, thereby inhibiting DNA replication and transcription.
• Carboplatin-based chemotherapy · Hoffmann-La Roche · Platinum-based chemotherapy · Oncology
  Platinum-based DNA alkylating agent
• Cisplatin & Nab Paclitaxel · Joyce O'Shaughnessy · Platinum-based alkylating agent and taxane · Oncology
  Cisplatin is a platinum-based alkylating agent that cross-links DNA, thereby inhibiting DNA replication and transcription. Nab-paclitaxel is a nanoparticle albumin-bound formulation of paclitaxel, which inhibits microtubule dynamics.
• Cisplatin based chemotherpay · Tata Memorial Centre · Platinum-based chemotherapeutic agent · Oncology
  Cisplatin works by crosslinking DNA, thereby inhibiting DNA replication and transcription.
• Carboplatin AUC7 · Centre Leon Berard · Platinum-based chemotherapy · Oncology
  Carboplatin works by interfering with DNA replication in cancer cells, leading to cell death.
• Carboplatin i.d. Days 1 & 15 · Windy Hill Medical, Inc. · Platinum-based chemotherapy · Oncology
  Carboplatin is a platinum-based chemotherapy drug that works by crosslinking DNA, thereby inhibiting cancer cell replication.
• IV Thiotepa · Assistance Publique - Hôpitaux de Paris · alkylating agent · Oncology
  Thiotepa is an alkylating agent that cross-links DNA, disrupting its structure and function, leading to cell death.
• FOLFOX induction regimen · Hoffmann-La Roche · Platinum-based chemotherapy · Oncology
  Oxaliplatin inhibits DNA replication by binding to DNA and inducing DNA damage.
• CarboP-pacliT · Centre Oscar Lambret · Platinum-based chemotherapy · Oncology
  CarboP-pacliT is a chemotherapy medication that works by interfering with DNA replication in cancer cells.
• Adjuvant FOLFOX · Asan Medical Center · Platinum-based chemotherapeutic agent and thymidylate synthase inhibitor · Oncology
  Oxaliplatin and 5-fluorouracil inhibit DNA replication and transcription by cross-linking DNA and interfering with thymidylate synthase.
• Cisplatin Combined With Topotecan · Chinese Anti-Cancer Association · Platinum-based chemotherapy · Oncology
  Cisplatin works by crosslinking DNA, thereby inhibiting DNA replication and transcription, while topotecan inhibits topoisomerase I, preventing DNA repair and replication.
• Consolidation Carboplatin · Radiation Therapy Oncology Group · Platinum-based chemotherapy · Oncology
  Carboplatin works by interfering with DNA replication in cancer cells, leading to cell death.
• Carboplatin AUC 5 IVa · Gruppo Oncologico Italiano di Ricerca Clinica · Platinum-based chemotherapy agent · Oncology
  Carboplatin is a platinum-based chemotherapy agent that forms DNA crosslinks, preventing cell replication and inducing apoptosis in cancer cells.
• Platinum Compound · SWOG Cancer Research Network · Platinum-based chemotherapy · Oncology
  Platinum-based chemotherapy agent that binds to DNA, inhibiting cancer cell replication
• BiCNU · VIVUS LLC · nitrogen mustard alkylating agent · Oncology
  BiCNU is a chemotherapy medication that works by interfering with DNA replication and cell division.
• CDDP 50 · Holy Name Medical Center, Inc. · Platinum-based chemotherapy · Oncology
  CDDP 50 is a platinum-based chemotherapy drug that works by crosslinking DNA, thereby inhibiting DNA replication and transcription.
• 2-chlorodeoxyadenosine · North American Consortium for Histiocytosis · purine nucleoside analog · Oncology
  2-chlorodeoxyadenosine is a purine nucleoside analog that inhibits DNA synthesis.