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Cisplatin based chemotherpay
Cisplatin works by crosslinking DNA, thereby inhibiting DNA replication and transcription.
Cisplatin works by crosslinking DNA, thereby inhibiting DNA replication and transcription. Used for Metastatic non-small cell lung cancer, Testicular cancer, Ovarian cancer.
At a glance
| Generic name | Cisplatin based chemotherpay |
|---|---|
| Sponsor | Tata Memorial Centre |
| Drug class | Platinum-based chemotherapeutic agent |
| Target | DNA |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 2 |
Mechanism of action
This leads to cell death, particularly in rapidly dividing cancer cells. Cisplatin also induces apoptosis and can cause DNA damage, further contributing to its anticancer effects.
Approved indications
- Metastatic non-small cell lung cancer
- Testicular cancer
- Ovarian cancer
- Bladder cancer
- Stomach cancer
Common side effects
- Nausea and vomiting
- Neutropenia
- Anemia
- Thrombocytopenia
- Kidney damage
Key clinical trials
- Study of Simultaneous Modulated Accelerated Radiation Therapy Concurrent With Chemotherapy to Treat Esophageal Cancer (PHASE2)
- Surgery Vs Chemoradiation for Oropharyngeal Cancer- A Phase II/III Integrated Design Randomized Control Trial (PHASE2, PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |