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Carboplatin (neoadjuvant）
Carboplatin is a platinum-based chemotherapy agent that forms DNA crosslinks to kill rapidly dividing cancer cells.
Carboplatin is a platinum-based chemotherapy agent that forms DNA crosslinks to kill rapidly dividing cancer cells. Used for Neoadjuvant chemotherapy for various solid tumors (specific indication depends on trial design).
At a glance
| Generic name | Carboplatin (neoadjuvant） |
|---|---|
| Sponsor | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University |
| Drug class | Platinum-based chemotherapy agent |
| Target | DNA |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
Carboplatin binds to DNA and forms interstrand and intrastrand crosslinks, preventing DNA replication and transcription. This leads to apoptosis of cancer cells. In neoadjuvant settings, it is administered before surgery to shrink tumors and improve surgical outcomes.
Approved indications
- Neoadjuvant chemotherapy for various solid tumors (specific indication depends on trial design)
Common side effects
- Myelosuppression (thrombocytopenia, neutropenia, anemia)
- Nausea and vomiting
- Nephrotoxicity
- Ototoxicity
- Peripheral neuropathy
- Allergic reactions
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