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Carboplatin AUC7
Carboplatin works by interfering with DNA replication in cancer cells, leading to cell death.
Carboplatin works by interfering with DNA replication in cancer cells, leading to cell death. Used for Advanced ovarian cancer, Small cell lung cancer, Non-small cell lung cancer.
At a glance
| Generic name | Carboplatin AUC7 |
|---|---|
| Sponsor | Centre Leon Berard |
| Drug class | Platinum-based chemotherapy |
| Target | DNA |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 2 |
Mechanism of action
Carboplatin is a platinum-based chemotherapy drug that forms platinum-DNA adducts, which prevent DNA replication and transcription, ultimately causing cell death. This mechanism is specific to rapidly dividing cells, such as cancer cells.
Approved indications
- Advanced ovarian cancer
- Small cell lung cancer
- Non-small cell lung cancer
Common side effects
- Myelosuppression
- Nausea and vomiting
- Neutropenia
- Thrombocytopenia
- Anemia
- Renal impairment
- Hearing loss
- Peripheral neuropathy
Key clinical trials
- THERApy De-escalation for TESTicular Cancer
- Reduced Intensity Radio-chemotherapy for Stage IIA/B Seminoma (PHASE2)
- Adjuvant Treatment in Extensive Unilateral Retinoblastoma Primary Enucleated (RB SFCE 2009) (PHASE2)
- Adjuvant Bleomycin, Etoposide and Cisplatin (BEP) Versus Carboplatin in Stage I Seminomatous Testicular Cancer (PHASE3)
- Therapy De-escalation in Seminoma Stage IIA/B (PHASE2)
- De-escalation Study for Stage IIa/IIb < 3 cm Seminoma (PHASE2)
- Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |