{"id":"carboplatin-auc7","safety":{"commonSideEffects":[{"rate":"30-50%","effect":"Myelosuppression"},{"rate":"20-40%","effect":"Nausea and vomiting"},{"rate":"20-40%","effect":"Neutropenia"},{"rate":"10-30%","effect":"Thrombocytopenia"},{"rate":"10-30%","effect":"Anemia"},{"rate":"5-20%","effect":"Renal impairment"},{"rate":"5-20%","effect":"Hearing loss"},{"rate":"5-20%","effect":"Peripheral neuropathy"}]},"_chembl":{"chemblId":"CHEMBL1351","moleculeType":"Small molecule","molecularWeight":"371.25"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Carboplatin is a platinum-based chemotherapy drug that forms platinum-DNA adducts, which prevent DNA replication and transcription, ultimately causing cell death. This mechanism is specific to rapidly dividing cells, such as cancer cells.","oneSentence":"Carboplatin works by interfering with DNA replication in cancer cells, leading to cell death.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T03:07:43.784Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Advanced ovarian cancer"},{"name":"Small cell lung cancer"},{"name":"Non-small cell lung cancer"}]},"trialDetails":[{"nctId":"NCT06309745","phase":"","title":"THERApy De-escalation for TESTicular Cancer","status":"RECRUITING","sponsor":"Queen Mary University of London","startDate":"2024-06-24","conditions":"Seminoma","enrollment":30},{"nctId":"NCT03937843","phase":"PHASE2","title":"Reduced Intensity Radio-chemotherapy for Stage IIA/B Seminoma","status":"ACTIVE_NOT_RECRUITING","sponsor":"Swiss Cancer Institute","startDate":"2019-07-29","conditions":"Seminoma, Testicular Cancer","enrollment":135},{"nctId":"NCT02870907","phase":"PHASE2","title":"Adjuvant Treatment in Extensive Unilateral Retinoblastoma Primary Enucleated (RB SFCE 2009)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Institut Curie","startDate":"2010-03-18","conditions":"Retinoblastoma","enrollment":195},{"nctId":"NCT02341989","phase":"PHASE3","title":"Adjuvant Bleomycin, Etoposide and Cisplatin (BEP) Versus Carboplatin in Stage I Seminomatous Testicular Cancer","status":"ACTIVE_NOT_RECRUITING","sponsor":"St. Olavs Hospital","startDate":"2015-04-08","conditions":"Testicular Neoplasms, Seminoma","enrollment":348},{"nctId":"NCT01593241","phase":"PHASE2","title":"Therapy De-escalation in Seminoma Stage IIA/B","status":"TERMINATED","sponsor":"Swiss Cancer Institute","startDate":"2012-06-15","conditions":"Seminoma","enrollment":120},{"nctId":"NCT05529251","phase":"PHASE2","title":"De-escalation Study for Stage IIa/IIb < 3 cm Seminoma","status":"RECRUITING","sponsor":"Centre Leon Berard","startDate":"2022-09-06","conditions":"Seminoma, Stage II","enrollment":90},{"nctId":"NCT00002931","phase":"PHASE2","title":"Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer","status":"COMPLETED","sponsor":"City of Hope Medical Center","startDate":"1997-02","conditions":"Brain and Central Nervous System Tumors, Extragonadal Germ Cell Tumor, Ovarian Cancer","enrollment":48}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":12,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"Carboplatin AUC7","genericName":"Carboplatin AUC7","companyName":"Centre Leon Berard","companyId":"centre-leon-berard","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Carboplatin works by interfering with DNA replication in cancer cells, leading to cell death. Used for Advanced ovarian cancer, Small cell lung cancer, Non-small cell lung cancer.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}