Alkylating agent
This page covers all Alkylating agent drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Tumor cell DNA, DNA, DNA (non-specific alkylation).
Targets
Tumor cell DNA · DNA · DNA (non-specific alkylation) · Topoisomerase II · DNA (non-specific cross-linking) · DNA (O6-guanine methylation)
Marketed (15)
- Cytoxan (Lyophilized) · Baxter · Oncology · 1000.0
Cyclophosphamide cross-links tumor cell DNA and interferes with malignant cell growth through active alkylating metabolites. - IFO · Italian Sarcoma Group · Oncology
Ifosfamide is an alkylating agent that cross-links DNA, preventing cell replication and inducing apoptosis. - Cyclophosphamide (CY) · Nanfang Hospital, Southern Medical University · Oncology, Immunology
Cyclophosphamide is an alkylating agent that cross-links DNA strands, preventing cell division and causing cancer cell death. - Cyclophosphamide (CYC) · Hansa Biopharma AB · Oncology, Immunology
Cyclophosphamide is an alkylating agent that cross-links DNA strands, preventing cell division and causing cell death in rapidly dividing cells. - CYC · Italian Sarcoma Group · Oncology
CYC is a cyclophosphamide-based chemotherapy agent that alkylates DNA to inhibit cancer cell proliferation. - post-transplantation cyclophosphamide · Peking University People's Hospital · Oncology / Immunology
Post-transplantation cyclophosphamide selectively eliminates alloreactive T cells after hematopoietic stem cell transplantation to reduce graft-versus-host disease while preserving graft-versus-leukemia effects. - cyclo phosphamide · Al-Azhar University · Oncology, Immunology
Cyclophosphamide is an alkylating agent that cross-links DNA strands, preventing cell division and causing cancer cell death. - Cyclophosphamide (C) · Second Affiliated Hospital, School of Medicine, Zhejiang University · Oncology, Immunology
Cyclophosphamide is an alkylating agent that cross-links DNA, preventing cell division and triggering apoptosis in rapidly dividing cells. - Treosulfan (Treo) · Federal Research Institute of Pediatric Hematology, Oncology and Immunology · Oncology
Treosulfan is an alkylating agent that cross-links DNA, causing cell death and used primarily as a myeloablative conditioning agent before hematopoietic stem cell transplantation. - Standard of Care: Cyclophosphamide · H. Lee Moffitt Cancer Center and Research Institute · Oncology
Cyclophosphamide is an alkylating agent that cross-links DNA strands, preventing cell division and causing cancer cell death. - Busulfan (BU) · Nanfang Hospital, Southern Medical University · Oncology
Busulfan is an alkylating agent that cross-links DNA, causing strand breaks and cell death, primarily used for myeloablation in hematopoietic stem cell transplantation. - Mitomycin-C sponge · University of California, San Diego · Oncology; Ophthalmology
Mitomycin-C is an antibiotic that alkylates DNA, causing cross-linking and cell death, used topically to prevent scar tissue formation after ocular surgery. - Mitomycin C 0.02% · Shahid Beheshti University of Medical Sciences · Oncology; Ophthalmology
Mitomycin C is an alkylating agent that cross-links DNA, preventing cell division and inducing apoptosis in rapidly dividing cells. - Melphalan Injection · Hospital das Clínicas de Ribeirão Preto · Oncology
Melphalan is an alkylating agent that cross-links DNA strands, preventing cell division and causing cancer cell death. - Melphalan (Mel) · Institute of Hematology & Blood Diseases Hospital, China · Oncology
Melphalan is an alkylating agent that cross-links DNA strands, preventing cell division and causing cancer cell death.
Phase 3 pipeline (29)
- intravenous busulfan · Alberta Health services · Oncology
Intravenous busulfan is an alkylating agent that interferes with DNA replication, leading to cell death in rapidly dividing cells. - VP16, ATG · St. Anna Kinderkrebsforschung · Oncology
VP16 is an alkylating agent that works by cross-linking DNA, thereby inhibiting DNA replication and transcription. - IV Cyclophosphamide · Johns Hopkins University · Oncology, Immunology
Cyclophosphamide is an alkylating agent that cross-links DNA strands, preventing cell division and triggering apoptosis in rapidly dividing cells. - concurrent temozolomide · Radiation Therapy Oncology Group · Oncology
Temozolomide is an alkylating agent that works by interfering with DNA replication in cancer cells. - Placebo-cyclophosphamide · Assistance Publique - Hôpitaux de Paris · Oncology
Cyclophosphamide is an alkylating agent that interferes with DNA replication, causing cell death. - Bendamustine hydrochloride injection · Jiangsu Simcere Pharmaceutical Co., Ltd. · Oncology
Bendamustine is an alkylating agent that cross-links DNA strands, causing cell death in rapidly dividing cancer cells. - Cyclophosphamide (CTX) · Asahi Kasei Pharma Corporation · Oncology, Immunology
Cyclophosphamide is an alkylating agent that cross-links DNA strands, preventing cell division and triggering apoptosis in rapidly dividing cells. - adjuvant temozolomide (TMZ) · Alliance for Clinical Trials in Oncology · Oncology
Temozolomide is an alkylating agent that works by interfering with DNA replication and transcription, thereby inhibiting cancer cell growth. - Ifosfamide or dacarbazine · Institut Bergonié · Oncology
Ifosfamide and dacarbazine are alkylating agents that cross-link DNA to prevent cancer cell replication, while dacarbazine also acts as a prodrug requiring metabolic activation. - cyclophosphamide or azathioprine · Sun Yat-sen University · Oncology
Cyclophosphamide and azathioprine are alkylating agents that interfere with DNA replication, thereby inhibiting cancer cell growth. - electromotive mitomycin · University of Rome Tor Vergata · Oncology
Electromotive mitomycin works by releasing mitomycin, an alkylating agent, directly into the tumor site. - ENDOXAN · Celyad Oncology SA · Oncology
ENDOXAN (cyclophosphamide) is an alkylating agent that cross-links DNA to inhibit cell division and induce apoptosis in rapidly dividing cells. - Mitomycin C (MMC) · Memorial Sloan Kettering Cancer Center · Oncology
Mitomycin C is an alkylating agent that cross-links DNA strands, preventing cell division and triggering cancer cell death. - R-MP and Procarbazine maintenance · University Hospital Freiburg · Oncology
R-MP and Procarbazine work together to target and kill cancer cells through a combination of DNA damage and inhibition of DNA repair. - carboplatin, thiotepa, and cyclophosphamide · The Netherlands Cancer Institute · Oncology
Carboplatin, thiotepa, and cyclophosphamide work by interfering with DNA replication and function, leading to cell death in rapidly dividing cancer cells. - concomitant temozolomide (TMZ) · Alliance for Clinical Trials in Oncology · Oncology
Temozolomide is an alkylating agent that works by interfering with DNA replication in cancer cells. - chlorambucil (drug) · International Extranodal Lymphoma Study Group (IELSG) · Oncology
Chlorambucil is an alkylating agent that cross-links DNA strands, preventing cell division and causing cancer cell death. - Ifosfamide for Injection · BeBetter Med Inc · Oncology
Ifosfamide is an alkylating agent that cross-links DNA strands, preventing cancer cell replication and inducing cell death. - Cyclophosphamide (drug) · University Hospital, Bordeaux · Oncology, Immunology
Cyclophosphamide is an alkylating agent that cross-links DNA strands, preventing cell division and triggering apoptosis in rapidly dividing cells. - Temozolomide + TACE · Taizhou Hanzhong biomedical co. LTD · Oncology
Temozolomide is an alkylating agent that works by interfering with DNA replication in cancer cells, while TACE is a minimally invasive procedure that involves the insertion of a catheter to deliver chemotherapy directly to the tumor. - busulfan (Busilvex ®) · PETHEMA Foundation · Oncology
Busulfan is an alkylating agent that interferes with DNA replication, leading to cell death. - High Dose Melphalan · M.D. Anderson Cancer Center · Oncology
High-dose melphalan is an alkylating agent that crosslinks DNA strands, causing cell death, and is used in high doses followed by stem cell rescue to treat hematologic malignancies. - cyclo, vcr, pred, dacarb,etop and doxo · University of Giessen · Oncology
Cyclophosphamide is an alkylating agent that interferes with DNA replication, causing cell death in rapidly dividing cells. - Dacarbazine (DTIC) · M.D. Anderson Cancer Center · Oncology
Dacarbazine is an alkylating agent that cross-links DNA, preventing cell division and causing cancer cell death. - Cyclophosphamide injections · Astellas Pharma China, Inc. · Oncology
Cyclophosphamide is an alkylating agent that cross-links DNA strands, preventing cell division and triggering apoptosis in rapidly dividing cells. - DTIC (dacarbazine) · University of Wuerzburg · Oncology
Dacarbazine is an alkylating agent that cross-links DNA, preventing cell replication and inducing apoptosis in cancer cells. - Standard cyclophosphamide · King Faisal Specialist Hospital & Research Center · Oncology
Cyclophosphamide works by interfering with the growth of cancer cells, which are eventually destroyed. - Temozolomide (TMZ) · Institut de Recherches Internationales Servier · Oncology
Temozolomide is an alkylating agent that methylates DNA at the O6 position of guanine, causing DNA strand breaks and cell death. - half cyclophosphamide · Gustave Roussy, Cancer Campus, Grand Paris · Oncology
Half-dose cyclophosphamide is a reduced-intensity alkylating agent that cross-links DNA to kill rapidly dividing cells, particularly in cancer and autoimmune contexts.
Phase 2 pipeline (3)
- IV Busulfan · Assistance Publique - Hôpitaux de Paris · Oncology
Alkylating agent that interferes with DNA replication - IV Thiotepa · Assistance Publique - Hôpitaux de Paris · Oncology
Thiotepa is an alkylating agent that cross-links DNA, disrupting its structure and function, leading to cell death. - Ifosphamide, Etoposide, Methotrexate, Vindelsine, Prednisone · Children's Cancer Group, China · Oncology
Topoisomerase inhibitor
Phase 1 pipeline (1)
- Alkylating-based chemotherapy · Hospices Civils de Lyon · Oncology
Alkylating agent that interferes with DNA replication