Topoisomerase II — Drug Target

All drugs that target Topoisomerase II — marketed and clinical-stage. Includes 11 drug classes acting on this target.

Drug classes

Topoisomerase II inhibitor · Liposomal anthracycline chemotherapy · Topoisomerase inhibitor · Alkylating agent · anthracycline · Anthracycline antibiotic · anthracycline antibiotic + alkylating agent · Topoisomerase II inhibitor; anthracycline · anthracycline antibiotic · anthracycline + alkylating agent · Chemotherapeutic agent

Marketed (5)

• Etoposide (ET) · Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections · Topoisomerase II inhibitor · Oncology
  Etoposide is a topoisomerase II inhibitor that prevents DNA religation, leading to DNA breaks and cell death in rapidly dividing cells.
• DOXORUBICIN HYDROCHLORIDE
  Doxorubicin works by intercalating DNA, inhibiting nucleotide replication, and forming DNA-cleavable complexes with topoisomerase II.
• DSP · Taiwan Liposome Company · Liposomal anthracycline chemotherapy · Oncology
  DSP is a liposomal doxorubicin formulation that delivers the chemotherapy agent doxorubicin within lipid nanoparticles to improve drug targeting and reduce systemic toxicity.
• VP-16 · PETHEMA Foundation · Topoisomerase II inhibitor · Oncology
  VP-16 (etoposide) is a topoisomerase II inhibitor that prevents DNA religation, leading to DNA strand breaks and cell death.
• ETO · Italian Sarcoma Group · Topoisomerase II inhibitor · Oncology
  ETO (etoposide) is a topoisomerase II inhibitor that prevents DNA religation, leading to DNA strand breaks and cell death.

Phase 3 pipeline (11)

• chemotherapy(c-ATT) · Sun Yat-sen University · Topoisomerase inhibitor · Oncology
  C-ATT works by targeting and inhibiting the function of cancer cells.
• VP16, ATG · St. Anna Kinderkrebsforschung · Alkylating agent · Oncology
  VP16 is an alkylating agent that works by cross-linking DNA, thereby inhibiting DNA replication and transcription.
• stealth liposomal doxorubicin · National Cancer Institute, Naples · anthracycline · Oncology
  Stealth liposomal doxorubicin is a formulation of doxorubicin that uses liposomes to improve its delivery and reduce its cardiotoxicity.
• vinflunine and best supportive care · Pierre Fabre Medicament · Anthracycline antibiotic · Oncology
  Vinflunine is a chemotherapeutic agent that works by intercalating DNA and inhibiting the enzyme topoisomerase II, thereby inducing apoptosis in cancer cells.
• doxorubicine + cyclophosphamide sequential · Sanofi · anthracycline antibiotic + alkylating agent · Oncology
  Doxorubicin is a topoisomerase II inhibitor that intercalates DNA, while cyclophosphamide is an alkylating agent that cross-links DNA.
• Amrubicin hydrocloride · Sumitomo Pharma Co., Ltd. · Topoisomerase II inhibitor; anthracycline · Oncology
  Amrubicin is a topoisomerase II inhibitor that intercalates into DNA and prevents the religation of DNA strands, leading to cell death.
• epidoxorubicine, ciclophosphamide, methotrexate, fluorouracile · Sanofi · anthracycline antibiotic · Oncology
  Epidoxorubicine is an anthracycline antibiotic that intercalates DNA strands, thereby inhibiting the progression of topoisomerase II and inducing apoptosis in cancer cells.
• Etoposide (VP-16) · The University of Hong Kong · Topoisomerase II inhibitor · Oncology
  Etoposide is a topoisomerase II inhibitor that prevents DNA religation, leading to DNA breaks and cancer cell death.
• non-pegylated liposomal doxorubicin · GBG Forschungs GmbH · anthracycline · Oncology
  Non-pegylated liposomal doxorubicin is a chemotherapy medication that works by intercalating DNA strands, thereby inhibiting the progression of the enzyme topoisomerase II and inducing apoptosis in cancer cells.
• doxorubicine + cyclophosphamide combined · Sanofi · anthracycline + alkylating agent · Oncology
  Doxorubicin is a topoisomerase II inhibitor that intercalates DNA, while cyclophosphamide is an alkylating agent that cross-links DNA.
• Oral chemotherapy · All India Institute of Medical Sciences · Chemotherapeutic agent · Oncology
  This oral chemotherapy drug works by interfering with DNA replication and cell division.

Phase 2 pipeline (6)

• ETOPOSIDE - Usual · Han Xu, M.D., Ph.D., FAPCR, Sponsor-Investigator, IRB Chair · Topoisomerase inhibitor · Oncology
  Etoposide is a topoisomerase II inhibitor that works by interfering with the enzyme topoisomerase II, which is involved in DNA replication and cell division.
• Amonafide L-Malate · Xanthus Pharmaceuticals, Inc. · Topoisomerase II inhibitor · Oncology
  Amonafide L-Malate is a quinazoline derivative that intercalates DNA, thereby inhibiting DNA synthesis and inducing apoptosis in cancer cells.
• 4-Demethyl-4-cholestryloxycarbonylpenclomedine · DEKK-TEC, Inc. · Topoisomerase II inhibitor · Oncology
  4-Demethyl-4-cholestryloxycarbonylpenclomedine is a chemotherapy medication that works by inhibiting the enzyme topoisomerase II.
• Doxorubicin Hydrochloride [HCl] · Genmab · Anthracycline antibiotic · Oncology
  Topoisomerase II inhibitor
• Ifosphamide, Etoposide, Methotrexate, Vindelsine, Prednisone · Children's Cancer Group, China · Alkylating agent · Oncology
  Topoisomerase inhibitor
• High-dose anthracycline · Gruppo Italiano Malattie EMatologiche dell'Adulto · anthracycline antibiotic · Oncology
  anthracyclines intercalate DNA strands, inhibiting topoisomerase II