Topoisomerase Inhibitor

This page covers all Topoisomerase Inhibitor drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Serine/threonine-protein kinase pim-1, Acetylcholinesterase, topoisomerase I.

Targets

Serine/threonine-protein kinase pim-1 · Acetylcholinesterase · topoisomerase I · Topoisomerase I · Topoisomerase II

Marketed (4)

• Novantrone · Oncology
  Novantrone works by interfering with the enzyme topoisomerase, which is necessary for DNA replication and cell division.
• Camptosar · Pfizer · Oncology
  Camptosar works by blocking the enzyme topoisomerase I, which is necessary for DNA replication, thereby preventing cancer cells from dividing and growing.
• Camptosar · Pfizer · Oncology
  Camptosar works by inhibiting topoisomerase I, an enzyme that helps DNA replicate, causing DNA damage and cancer cell death.
• Camptosar · Pfizer · Oncology
  Irinotecan and its metabolite SN-38 bind to the topoisomerase I-DNA complex, preventing DNA repair and causing double-strand breaks.

Phase 3 pipeline (2)

• Topotecan (Chemotherapy) · Hoffmann-La Roche · Oncology
  Topotecan is a topoisomerase I inhibitor that works by interfering with the enzyme topoisomerase I, which is involved in DNA replication and repair.
• chemotherapy(c-ATT) · Sun Yat-sen University · Oncology
  C-ATT works by targeting and inhibiting the function of cancer cells.

Phase 2 pipeline (3)

• CPT-11, 5-FU and l-LV · Taiho Pharmaceutical Co., Ltd. · Oncology
  Topoisomerase I inhibitor
• ETOPOSIDE - Usual · Han Xu, M.D., Ph.D., FAPCR, Sponsor-Investigator, IRB Chair · Oncology
  Etoposide is a topoisomerase II inhibitor that works by interfering with the enzyme topoisomerase II, which is involved in DNA replication and cell division.
• Intravitreal topotecan · Unity Health Toronto · Oncology
  Topoisomerase I inhibitor