topoisomerase I — Drug Target

All drugs that target topoisomerase I — marketed and clinical-stage. Includes 4 drug classes acting on this target.

Drug classes

Topoisomerase Inhibitor · Topoisomerase inhibitor · Topoisomerase I inhibitor · Liposomal topoisomerase I inhibitor

Marketed (1)

• Camptosar · Pfizer · Topoisomerase Inhibitor · Oncology
  Irinotecan and its metabolite SN-38 bind to the topoisomerase I-DNA complex, preventing DNA repair and causing double-strand breaks.

Phase 3 pipeline (11)

• Topotecan (Chemotherapy) · Hoffmann-La Roche · Topoisomerase inhibitor · Oncology
  Topotecan is a topoisomerase I inhibitor that works by interfering with the enzyme topoisomerase I, which is involved in DNA replication and repair.
• CPT-11 (Irinotecan) · Epidemiological and Clinical Research Information Network · Topoisomerase I inhibitor · Oncology
  CPT-11 (irinotecan) is a topoisomerase I inhibitor that prevents DNA unwinding and repair, leading to DNA damage and cancer cell death.
• MM-398 · Ipsen · Liposomal topoisomerase I inhibitor · Oncology
  MM-398 is a liposomal formulation of irinotecan that delivers the topoisomerase I inhibitor directly to tumor cells while reducing systemic toxicity.
• Oral Topotecan · Accelerated Community Oncology Research Network · Topoisomerase I inhibitor · Oncology
  Oral topotecan inhibits topoisomerase I, an enzyme required for DNA replication, causing DNA damage and cancer cell death.
• Irinotecan Liposomal · The First Affiliated Hospital of Zhengzhou University · Topoisomerase I inhibitor · Oncology
  Irinotecan liposomal is a topoisomerase I inhibitor encapsulated in liposomes that prevents DNA religation during replication, leading to cell death.
• Irinotecan Based Chemotherapy · Amgen · Topoisomerase I inhibitor · Oncology
  Irinotecan is a topoisomerase I inhibitor that prevents DNA religation during replication, leading to DNA damage and cancer cell death.
• Irinotecan Liposomal Injection [Onivyde] · Seoul National University Hospital · Topoisomerase I inhibitor · Oncology
  Irinotecan liposomal injection is a topoisomerase I inhibitor encapsulated in liposomes that prevents DNA unwinding and causes cancer cell death.
• Liposomal irinotecan · St. Jude Children's Research Hospital · Topoisomerase I inhibitor · Oncology
  Liposomal irinotecan is a nanoparticle formulation of the topoisomerase I inhibitor irinotecan that delivers the chemotherapy agent to tumor cells while reducing systemic toxicity.
• Irinotecan Injection · Chinese Academy of Medical Sciences · Topoisomerase I inhibitor · Oncology
  Irinotecan is a topoisomerase I inhibitor that prevents DNA religation during replication, leading to DNA damage and cancer cell death.
• HYCAMTIN, oral capsules · GlaxoSmithKline · Topoisomerase I inhibitor · Oncology
  Topotecan inhibits topoisomerase I, an enzyme required for DNA replication, causing DNA damage and cell death in rapidly dividing cancer cells.
• Hydroxycamptothecin for Injection · Suzhou Suncadia Biopharmaceuticals Co., Ltd. · Topoisomerase I inhibitor · Oncology
  Hydroxycamptothecin inhibits topoisomerase I, preventing DNA relaxation and causing DNA damage in rapidly dividing cancer cells.

Phase 2 pipeline (4)

• G17DT-Irinotecan · Cancer Advances Inc. · Topoisomerase I inhibitor · Oncology
  G17DT-Irinotecan is a topoisomerase I inhibitor, which works by blocking the enzyme topoisomerase I and preventing DNA replication in cancer cells.
• CPT-11, 5-FU and l-LV · Taiho Pharmaceutical Co., Ltd. · Topoisomerase inhibitor · Oncology
  Topoisomerase I inhibitor
• CPT-11 based regimens · Daiichi Sankyo Co., Ltd. · Topoisomerase I inhibitor · Oncology
  CPT-11 is a topoisomerase I inhibitor that works by stabilizing the cleavage complex of DNA and RNA, thereby inhibiting DNA replication and transcription.
• Intravitreal topotecan · Unity Health Toronto · Topoisomerase inhibitor · Oncology
  Topoisomerase I inhibitor