Acetylcholinesterase — Drug Target

All drugs that target Acetylcholinesterase — marketed and clinical-stage. Includes 14 drug classes acting on this target.

Drug classes

demecarium · Cholinesterase inhibitor · Cholinesterase Inhibitor · Topoisomerase Inhibitor · Cholinesterase Reactivator · physostigmine · Acetylcholinesterase reactivator (oxime) · distigmine · dyclonine · Acetylcholinesterase inhibitor · Organophosphate insecticide · obidoxime

Marketed (21)

• Demekarium Bromide · demecarium · Ophthalmology
• TIVA - Neostigmine 50 · Pontificia Universidade Catolica de Sao Paulo · Cholinesterase inhibitor · Neurology
  Neostigmine inhibits acetylcholinesterase, increasing acetylcholine levels at the neuromuscular junction to enhance muscle contraction.
• IMIDOCARB · Neuroscience
• Mytelase · Sanofi · Cholinesterase Inhibitor · Neuroscience
• Tensilon · Cholinesterase Inhibitor · Neuroscience
• Razadyne · Johnson & Johnson · Cholinesterase Inhibitor · Neuroscience
  Razadyne works by blocking the enzyme that breaks down acetylcholine, allowing more of this neurotransmitter to be available in the brain.
• Camptosar · Pfizer · Topoisomerase Inhibitor · Oncology
  Camptosar works by blocking the enzyme topoisomerase I, which is necessary for DNA replication, thereby preventing cancer cells from dividing and growing.
• Pralidoxime Chloride (Autoinjector) · Baxter · Cholinesterase Reactivator · Neuroscience
  Pralidoxime Chloride works by reactivating the enzyme acetylcholinesterase, which is inhibited by organophosphate poisoning.
• Phospholine Iodide · Fera Pharms Llc · Cholinesterase Inhibitor · Neuroscience
• Camptosar · Pfizer · Topoisomerase Inhibitor · Oncology
  Camptosar works by inhibiting topoisomerase I, an enzyme that helps DNA replicate, causing DNA damage and cancer cell death.
• Cogmine · physostigmine · Neuroscience
• Caroxime sodium sulfonate · Chengdu University of Traditional Chinese Medicine · Acetylcholinesterase reactivator (oxime) · Toxicology / Antidote
  Caroxime sodium sulfonate is an oxime compound that acts as an acetylcholinesterase reactivator, restoring cholinergic neurotransmission by removing phosphoryl groups from inhibited enzyme active sites.
• Neostigmine Injection · Taipei Veterans General Hospital, Taiwan · Cholinesterase inhibitor · Neurology
  Neostigmine inhibits acetylcholinesterase, allowing acetylcholine to accumulate at neuromuscular junctions and enhance muscle contraction.
• Acofide · Zeria · Neuroscience
• Ubretid · Torii Pharmaceuticals · distigmine · Neuroscience
• Bloxiverz · Fresenius Kabi · Cholinesterase Inhibitor · Neuroscience
  Bloxiverz works by blocking the enzyme acetylcholinesterase, allowing more acetylcholine to be available in the nervous system.
• Toxogonin · Aya Sabry Mohamed Mohamed · Other
• Dyclone · dyclonine · Neuroscience
• Huperzine A Injection · Second Affiliated Hospital of Wenzhou Medical University · Acetylcholinesterase inhibitor · Neurology
  Huperzine A inhibits acetylcholinesterase, increasing acetylcholine levels in the brain to improve cognitive function.
• Neostigmine, Atropin Biotika · University Hospital Olomouc · Cholinesterase inhibitor · Neurology
  Neostigmine inhibits acetylcholinesterase, allowing acetylcholine to accumulate at neuromuscular junctions and enhance muscle contraction.
• TIVA - Neostigmine 70 · Pontificia Universidade Catolica de Sao Paulo · Acetylcholinesterase inhibitor · Neurology
  Neostigmine is a reversible acetylcholinesterase inhibitor that increases acetylcholine levels at the neuromuscular junction and in the central nervous system.

Phase 3 pipeline (10)

• Rivastigmine prevention of delirium · University Hospital, Basel, Switzerland · Cholinesterase inhibitor · Neurology
  Rivastigmine is a cholinesterase inhibitor that works by increasing the concentration of acetylcholine in the brain, which helps to improve cognitive function and prevent delirium.
• Donepezil drug treatment · Shanghai Jiao Tong University School of Medicine · Acetylcholinesterase inhibitor · Neurology
  Donepezil inhibits acetylcholinesterase, increasing acetylcholine levels in the brain to improve cognitive function in Alzheimer's disease.
• Aricept (donepezil SR 23 mg) · Eisai Inc. · Acetylcholinesterase inhibitor · Neurology
  Donepezil is an acetylcholinesterase inhibitor that increases acetylcholine levels in the brain by blocking the enzyme that breaks it down.
• Rivastigmine 10 cm^2 transdermal patch · Novartis · Cholinesterase inhibitor · Neurology
  Rivastigmine is a cholinesterase inhibitor that works by increasing the concentration of acetylcholine in the brain, which helps to improve cognitive function in patients with Alzheimer's disease.
• aricept Tab · Icure Pharmaceutical Inc. · Cholinesterase inhibitor · Neurology
  Aricept (donepezil) is a cholinesterase inhibitor that works by increasing the concentration of acetylcholine in the brain, which helps to improve cognitive function in patients with Alzheimer's disease.
• Malathion Shampoo 0.5% · London School of Hygiene and Tropical Medicine · Organophosphate insecticide · Parasitology / Dermatology
  Malathion is an organophosphate insecticide that inhibits acetylcholinesterase in parasitic arthropods, causing paralysis and death.
• Placebo to neostigmine · Merck Sharp & Dohme LLC · Cholinesterase inhibitor · Neurology
  Neostigmine is a cholinesterase inhibitor that increases acetylcholine levels by blocking the enzyme acetylcholinesterase, enhancing neuromuscular transmission.
• Octohydroaminoacridine Succinate · Shanghai Mental Health Center · Acetylcholinesterase inhibitor · Neurology
  Octohydroaminoacridine succinate is a cognitive enhancer that likely increases acetylcholine levels in the brain by inhibiting acetylcholinesterase.
• Malathion gel 0.5% · Sun Pharmaceutical Industries, Inc. · Organophosphate insecticide · Dermatology / Parasitology
  Malathion is an organophosphate insecticide that inhibits acetylcholinesterase, causing accumulation of acetylcholine and paralysis of parasites.
• Cholinesterase Inhibitor · Sunnybrook Health Sciences Centre · Cholinesterase inhibitor · Neurology
  Cholinesterase inhibitors block the enzyme that breaks down acetylcholine, allowing acetylcholine to accumulate in the synapse and enhance cholinergic neurotransmission.

Phase 2 pipeline (6)

• Obidoxim · obidoxime · Neuroscience
  Obidoxim works by reactivating Acetylcholinesterase, an enzyme that breaks down acetylcholine, a neurotransmitter.
• E2020-Donepezil hydrochloride · Eisai Co., Ltd. · Cholinesterase inhibitor · Neurology
  Donepezil hydrochloride is a cholinesterase inhibitor that works by increasing the concentration of acetylcholine in the brain, which helps to improve cognitive function in patients with Alzheimer's disease.
• Propentophylline · propentofylline · Neuroscience
  Propentofylline works by inhibiting the enzyme acetylcholinesterase, which breaks down the neurotransmitter acetylcholine.
• Amiridine · ipidacrine · Neuroscience
  Amiridine works by inhibiting the enzyme Acetylcholinesterase, which breaks down the neurotransmitter acetylcholine.
• Aricept® Evess · Pfizer · Cholinesterase inhibitor · Neurology
  Aricept Evess is a cholinesterase inhibitor that works by increasing the concentration of acetylcholine in the brain.
• Huperzine A Controlled-Release Tablets · Wanbangde Pharmaceutical Group Co., LTD · Cholinesterase inhibitor · Neurology
  Huperzine A is a reversible cholinesterase inhibitor that increases acetylcholine levels in the brain.