Cholinesterase Inhibitor

This page covers all Cholinesterase Inhibitor drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Sigma non-opioid intracellular receptor 1, Acetylcholinesterase and butyrylcholinesterase, Acetylcholinesterase.

Targets

Sigma non-opioid intracellular receptor 1 · Acetylcholinesterase and butyrylcholinesterase · Acetylcholinesterase · Acetylcholinesterase; Butyrylcholinesterase · Acetylcholinesterase; nicotinic acetylcholine receptors

Marketed (13)

• Aricept · Eisai · Neuroscience · 800
  Aricept works by blocking the enzyme that breaks down a key neurotransmitter in the brain, acetylcholine.
• Rivastigmine Patch 9.5 cm2 · University of California, San Francisco · Neurology
  Rivastigmine is a cholinesterase inhibitor that increases acetylcholine levels in the brain by blocking the enzyme that breaks it down.
• Mytelase · Sanofi · Neuroscience
• Tensilon · Neuroscience
• Razadyne · Johnson & Johnson · Neuroscience
  Razadyne works by blocking the enzyme that breaks down acetylcholine, allowing more of this neurotransmitter to be available in the brain.
• Phospholine Iodide · Fera Pharms Llc · Neuroscience
• Rivastigmine transdermal patch · Novartis · Neurology
  Rivastigmine is a cholinesterase inhibitor that increases acetylcholine levels in the brain by blocking the enzyme that breaks it down.
• Exelon (rivastigmine) · Singapore General Hospital · Neurology
  Rivastigmine inhibits acetylcholinesterase and butyrylcholinesterase enzymes, increasing acetylcholine levels in the brain to improve cognitive function in dementia.
• Rivastigmine patch · Chung-Ang University Hosptial, Chung-Ang University College of Medicine · Neurology
  Rivastigmine is a cholinesterase inhibitor that increases acetylcholine levels in the brain by blocking the enzyme that breaks it down.
• Neostigmine Injection · Taipei Veterans General Hospital, Taiwan · Neurology
  Neostigmine inhibits acetylcholinesterase, allowing acetylcholine to accumulate at neuromuscular junctions and enhance muscle contraction.
• TIVA - Neostigmine 50 · Pontificia Universidade Catolica de Sao Paulo · Neurology
  Neostigmine inhibits acetylcholinesterase, increasing acetylcholine levels at the neuromuscular junction to enhance muscle contraction.
• Neostigmine, Atropin Biotika · University Hospital Olomouc · Neurology
  Neostigmine inhibits acetylcholinesterase, allowing acetylcholine to accumulate at neuromuscular junctions and enhance muscle contraction.
• Bloxiverz · Fresenius Kabi · Neuroscience
  Bloxiverz works by blocking the enzyme acetylcholinesterase, allowing more acetylcholine to be available in the nervous system.

Phase 3 pipeline (7)

• Cholinesterase Inhibitor · Sunnybrook Health Sciences Centre · Neurology
  Cholinesterase inhibitors block the enzyme that breaks down acetylcholine, allowing acetylcholine to accumulate in the synapse and enhance cholinergic neurotransmission.
• Placebo to neostigmine · Merck Sharp & Dohme LLC · Neurology
  Neostigmine is a cholinesterase inhibitor that increases acetylcholine levels by blocking the enzyme acetylcholinesterase, enhancing neuromuscular transmission.
• aricept Tab · Icure Pharmaceutical Inc. · Neurology
  Aricept (donepezil) is a cholinesterase inhibitor that works by increasing the concentration of acetylcholine in the brain, which helps to improve cognitive function in patients with Alzheimer's disease.
• Rivastigmine prevention of delirium · University Hospital, Basel, Switzerland · Neurology
  Rivastigmine is a cholinesterase inhibitor that works by increasing the concentration of acetylcholine in the brain, which helps to improve cognitive function and prevent delirium.
• Rivastigmine 10 cm^2 transdermal patch · Novartis · Neurology
  Rivastigmine is a cholinesterase inhibitor that works by increasing the concentration of acetylcholine in the brain, which helps to improve cognitive function in patients with Alzheimer's disease.
• Extended-release galantamine hydrobromide · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. · Neurology
  Galantamine is a cholinesterase inhibitor that increases acetylcholine levels in the brain by blocking its breakdown, and also acts as an allosteric modulator of nicotinic receptors.
• Rivastigmine 5 cm^2 transdermal patch · Novartis · Neurology
  Rivastigmine inhibits acetylcholinesterase and butyrylcholinesterase enzymes, increasing acetylcholine levels in the brain to improve cognitive function.

Phase 2 pipeline (3)

• Aricept® Evess · Pfizer · Neurology
  Aricept Evess is a cholinesterase inhibitor that works by increasing the concentration of acetylcholine in the brain.
• E2020-Donepezil hydrochloride · Eisai Co., Ltd. · Neurology
  Donepezil hydrochloride is a cholinesterase inhibitor that works by increasing the concentration of acetylcholine in the brain, which helps to improve cognitive function in patients with Alzheimer's disease.
• Huperzine A Controlled-Release Tablets · Wanbangde Pharmaceutical Group Co., LTD · Neurology
  Huperzine A is a reversible cholinesterase inhibitor that increases acetylcholine levels in the brain.